US2002133229A1PendingUtilityA1

Ligament and tendon replacement constructs and methods for production and use thereof

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Priority: Mar 24, 2000Filed: Jun 11, 2001Published: Sep 19, 2002
Est. expiryMar 24, 2020(expired)· nominal 20-yr term from priority
Inventors:Cato T. LaurencinFrank KoJames CooperHelen H. LuMohammed Attawia
A61L 2430/10A61L 27/56A61L 27/18A61F 2230/0019A61F 2230/0006A61L 27/58A61F 2/40A61F 2/38A61F 2210/0004A61F 2/08
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Claims

Abstract

Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A replacement construct comprising a degradable, polymeric fiber-based, three-dimensional braided scaffold.  
     
     
         2 . A replacement construct comprising a degradable polymeric fiber-based, three-dimensional braided scaffold seeded with cells, ingrowth of which is support by the scaffold.  
     
     
         3 . The replacement construct of  claim 2  where the cells are mesenchymal in origin.  
     
     
         4 . The replacement construct of  claim 2  wherein the cells generate mesenchymal cells.  
     
     
         5 . The replacement construct of  claim 4  wherein the cells are pluripotent stem cells.  
     
     
         6 . A method for repairing, replacing or reconstructing a damaged tendon or ligament in a patient comprising implanting at a damaged tendon or ligament the replacement construct of  claim 1 .  
     
     
         7 . A method for repairing, replacing or reconstructing a damaged tendon or ligament in a patient comprising implanting at a damaged tendon or ligament the replacement construct of  claim 2 .  
     
     
         8 . A method for producing a graft material composed of living cells in a degradable matrix comprising: 
 (a) harvesting, growing and passaging cells in tissue culture; and    (b) seeding the cultured cells onto the degradable, polymeric fiber-based, three-dimensional braided scaffold of  claim 1 .    
     
     
         9 . The method of  claim 8  wherein the cells are mesenchymal in origin.  
     
     
         10 . The method of  claim 8  wherein the cells generate mesenchymal cells.  
     
     
         11 . The method of  claim 10  wherein the cells are pluripotent stem cells.

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