Solid phase dispersion of quinolone-or naphthyridonecarboxylic acids

Abstract

The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals.

What is claimed is:  
     
         1 . A solid phase dispersion comprising a quinolone- or naphthyridonecarboxylic acid in an insoluble matrix.  
     
     
         2 . The dispersion according to  claim 1 , wherein the insoluble matrix is selected from the group consisting of shellac, high molecular weight polyethylene glycol polyvinyl alcohol, poly(D.L.-lactic co glycolic and sugars.  
     
     
         3 . The dispersion according to  claim 2 , wherein the insoluble matrix is shellac.  
     
     
         4 . The dispersion of  claim 1 , wherein quinolone- or naphthyridonecarboxylic acid and the insoluble matrix are in a ratio of 1:0.5 to 10.  
     
     
         5 . The dispersion of  claim 4 , wherein quinolone- or naphthyridonecarboxylic acid and the insoluble matrix are in a ratio of 1:5.  
     
     
         6 . A method of preparing a solid dispersion of a quinolone- or naphthyridonecarboxylic acid, comprising forming a hydrate of the quinolone- or naphthyridonecarboxylic acid, mixing quinolone- or naphthyridonecarboxylic acid with an insoluble matrix, heating the mixture until it flows, and micronizing the mixture.  
     
     
         7 . A feed formulation comprising feedstuff and the solid phase dispersion of  claim 1 .  
     
     
         8 . A process for improving animal uptake of quinolone- or naphthyridonecarboxylic acid comprising orally administering to the animal a solid phase dispersion of a quinolone- or naphthyridonecarboxylic acid and an insoluble matrix in an effective amount to mask the taste of the active.