Rhinologically active substances

Abstract

Acyclic ethers can be used as rhinologically active substances. In the regions of the mouth, the throat and the airways they produce a refreshing and clearing feeling.

What is claimed is:  
     
         1 . Rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         2 . Rhinologically active substances according to  claim 1 , wherein 
 R 1  denotes a methyl or ethyl group, and    R 3  denotes a monocyclic carbon system having 6 or 7 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 3 carbon atoms and/or alkenyl groups having 3 carbon atoms.    
     
     
         3 . Rhinologically active substances according to  claim 1 , wherein said rhinologically active substances are selected from the group consisting of l-menthyl methyl ether, d-menthyl methyl ether, dl-menthyl methyl ether, menthyl ethyl ether, menthyl propyl ether, menthyl isobutyl ether, isopulegyl methyl ether, 2-isopropylcyclohexyl methyl ether, 2-isopropylcyclohexyl ethyl ether, 3,3,5-trimethylcyclohexyl methyl ether, 1-(3,3-dimethylcyclohexyl)ethyl ethyl ether, 1-(3,3-dimethylcyclohexyl)ethyl propyl ether, and 1-(3,3-dimethylcyclohexyl)ethyl methyl ether.  
     
     
         4 . Preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         5 . Preparations having a refreshing activity according to  claim 4 , wherein 
 R 1  denotes a methyl or ethyl group, and    R 3  denotes a monocyclic carbon system having 6 or 7 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 3 carbon atoms and/or alkenyl groups having 3 carbon atoms.    
     
     
         6 . Preparations having a refreshing activity according to  claim 4 , comprising rhinologically active substances selected from the group consisting of l-menthyl methyl ether, d-menthyl methyl ether, dl-menthyl methyl ether, menthyl ethyl ether, menthyl propyl ether, menthyl isobutyl ether, isopulegyl methyl ether, 2-isopropylcyclohexyl methyl ether, 2-isopropylcyclohexyl ethyl ether, 3,3,5-trimethylcyclohexyl methyl ether, 1-(3,3-dimethylcyclohexyl)ethyl ethyl ether, 1-(3,3-dimethylcyclohexyl)ethyl propyl ether, and 1-(3,3-dimethylcyclohexyl)ethyl methyl ether.  
     
     
         7 . Preparations having a refreshing activity according to  claim 4 , wherein said preparations comprise 0.0001 to 10% by weight of said rhinologically active substances.  
     
     
         8 . An oral care composition comprising preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         9 . An oral care composition according to  claim 8 , wherein said oral care composition is a toothpaste.  
     
     
         10 . An oral care composition according to  claim 8 , wherein said oral care composition is a mouthwash.  
     
     
         11 . An oral care composition according to  claim 8 , wherein said oral care composition is a chewing-gum.  
     
     
         12 . A food product comprising preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         13 . Tobacco products comprising preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         14 . Confectionary products comprising preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         15 . Pharmaceutical preparations having a refreshing activity comprising rhinologically active substances of the formula  
       
         
           
           
               
               
           
         
       
       wherein 
 x is 0 or 1,  
 R 1  denotes an alkyl group having 1 to 4 carbon atoms,  
 R 2  denotes a methyl or ethyl group and  
 R 3  denotes a monocyclic carbon system having 5, 6, 7 or 8 carbon atoms that can be unsubstituted or substituted with further alkyl groups having 1 to 4 carbon atoms or alkenyl groups having 2 to 4 carbon atoms.  
 
     
     
         16 . Novel acyclic ethers selected from the group consisting of isopulegyl methyl ether, 1-(3,3-dimethylcyclohexyl)ethyl ethyl ether, 1-(3,3-dimethylcyclohexyl)ethyl propyl ether and 1-(3,3-dimethylcyclohexyl)ethyl methyl ether.