Agents for treating neurodegenerative disorders

Abstract

Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of neurodegenerative diseases can be represented by a general formula (I): wherein R 1 is Me, Et or PhCH 2 ; R 2 is H, PHCH 2 or 6-Me-3-Py-(CH 2 ) 2 ; and R 3 is H, Me or Br. The solid line accompanied by the dotted line, i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives.

What is claimed is:  
     
         1 . Use of the hydrogenated pyrido [4,3-b] indole derivatives of the formula (I)  
       
         
           
           
               
               
           
         
       
       wherein R 1  is Me, Et or PhCH 2 ; 
 R 2  is H, PhCH 2  or 6-Me-3-Py-(CH 2 ) 2 ;  
 R 3  is H, Me or Br; provided that  
 (a) when  represents a single bond, then  
 R 1  R 3  Me; R 2  H; and the compound is in the form of a cis (±) isomer; or  
 (b) when  represents a double bond, then  
 (i) R 1 =Et or PhCH 2 , R 2 =R 3 =H.  
 (ii) R 1 =R 3 =Me, R 2 =PhCH 2 .  
 (iii) R 1 =Me, R 2 =6-Me-3-Py-(CH 2 ) 2 , R 3 =H,  
 (iv) R 1 =R 3 =Me, R 2 =6-Me-3-Py-(CH 2 ) 2 ,  
 (v) R 1 =Me, R 2 =H, R 3 =H or Me,  
 (vi) R 1 =Me, R 2 =H, R 3 =Br,  
 and salts thereof with pharmacologically acceptable acids and quaternary derivatives as the agents for the treatment of neurodegenerative diseases.