Method for treating patients with neoplasia by administering substituted sulfonyl indenyl acetic and propionic acids and esters thereof

Abstract

Substituted indenyl sulfonyl acetic acids are useful in the treatment of precancerous lesions.

We claim:  
     
         1 . A method for treating a patient with neoplasia, comprising administering to the patient a physiologically effective amount of a compound of the formula A:  
       
         
           
           
               
               
           
         
         Wherein R 1  is selected from the group consisting of hydrogen, lower alkyl, or haloalkyl;  
         R 2  is selected from the group consisting of hydrogen or alkyl;  
         R 3  and R 4  are one or more members each independently chosen from the group consisting of hydrogen, alkyl, acyloxy, alkoxy, nitro, amino, acylamino, alkylamino, diakylamino, dialkylaminoalkyl, sulfamyl, alkythio, mercapto, hydroxy, hydroxyalkyl, alkylsulfonyl, halogen, cyano, carboxyl, carbalkoxy, carbamido, haloalkyl or cycloalkoxy;  
         R 5  is an alkylsulfonyl;  
         M is selected from the group consisting of hydroxy, substituted lower alkoxy, amino, alkylamino, dialkylamino, N-morpholino, hydroxyalkylamino, polyhydroxyamino, dialkylaminoalkylamino, aminoalklyamino, and the group Ome, wherein Me is a cation; and  
         m and n each equal 1.  
       
     
     
         2 . A method according to  claim 1  wherein R 3  and R 4  are selected from alkyl, acyloxy, alkoxy, halogen, haloalkyl or cycloalkoxy.  
     
     
         3 . A method according to  claim 2  wherein R 1  is hydrogen.  
     
     
         4 . A method according to  claim 1  wherein said compound is administered orally.  
     
     
         5 . A method according to  claim 1  wherein said compound is administered orally by unit dosage in a pharmaceutically acceptable carrier.  
     
     
         6 . A method according to  claim 1  wherein M is hydroxy or methoxy.  
     
     
         7 . The method according to  claim 1  wherein said compound is enterically coated for colonic release.  
     
     
         8 . The method according to  claim 1  that comprises treating a patient with colonic polyps by administering to the patient a pharmacologically effective amount of the compound of formula A.  
     
     
         9 . The method according to  claim 1  that comprises treating a patient with precancerous lesions of the breast by administering to the patient a pharmacologically effective amount of the compound of formula A.  
     
     
         10 . The method according to  claim 1  that comprises treating a patient with precancerous lesions of the skin by administering the patient a pharmacologically effective amount of the compound of formula A.