Galenical formulation

Abstract

The invention relates to compounds of the formula I where R 1 , R 2 , R 3 , R 4 and R 5 have the meanings given in claim 1. The compound is suitable in particular for use in skin care compositions. They protect, firstly, against harmful oxidation reactions and, secondly, also act as UV filters.

1 . A compounds of the formula I  
       
         
           
           
               
               
           
         
       
       where 
 X is O, S or NH;  
 Y is O, S or NH;  
 a single or double bond may be provided between carbons C-2 and C-3,  
 R 1  and R 2 , and R 3  and R 4  may be provided at any positions on the ring, and also  
 R 1 , R 2 , R 3 , R 4  and R 5  may be identical or different and independently of one another are —H, —OH or —OA, and  
 A is a group which absorbs UV radiation selected from the group formed from:  
                     
 and at least one of the groups R 1 , R 2 , R 3 , R 4  or R 5  is formed by —OA.  
 
     
     
         2 . A compound of formula I  
       
         
           
           
               
               
           
         
       
       where 
 X is O, S or NH;  
 Y is O, S or NH;  
 a single or double bond may be provided between carbons C-2 and C-3,  
 R 1  and R 2 , and R 3  and R 4  may be provided at any positions on the ring, and also  
 R 1 , R 2 , R 3 , R 4  and R 5  may be identical or different and independently of one another are —H, —OH or —OA,  
 in addition R 1 , R 2 , R 3 , R 4  and R 5 , independently of one another, can stand for a 
 straight-chain or branched oxyalkyl or carboxyalkyl group having 1 to 12 carbon atoms,  
 straight-chain or branched oxyalkenyl or carboxyalkenyl group having 2 to 12 carbon atoms,  
 straight-chain or branched hydroxyoxyalkyl group having 1 to 12 carbon atoms, where the hydroxyl group may be bonded to a primary or secondary carbon atom and, furthermore, the alkyl chain can also be interrupted by oxygen,  
 sulphate group,  
 phosphate group  
 and a mono- or oligoglycosyl radical, and  
 
 A is a group which absorbs UV radiation selected from the group formed from:  
                     
 and at least one of the groups R 1 , R 2 , R 3 , R 4  or R 5  is formed by —OA.  
 
     
     
         3 . A compound according to  claim 1 , wherein said compound is of formula II  
       
         
           
           
               
               
           
         
       
     
     
         4 . A compound according to  claim 2 , wherein said compound is of formula II  
       
         
           
           
               
               
           
         
       
     
     
         5 . In a cosmetic or pharmaceutical formulation comprising an active ingredient and a physiologically acceptable carrier, the improvement wherein said formulation comprises at least one compound according to  claim 1 .  
     
     
         6 . In a cosmetic or pharmaceutical formulation comprising an active ingredient and a physiologically acceptable carrier, the improvement wherein said formulation comprises at least one compound according to  claim 2 .  
     
     
         7 . In a cosmetic or pharmaceutical formulation comprising an active ingredient and a physiologically acceptable carrier, the improvement wherein said formulation comprises at least one compound according to  claim 3 .  
     
     
         8 . In a cosmetic or pharmaceutical formulation comprising an active ingredient and a physiologically acceptable carrier, the improvement wherein said formulation comprises at least one compound according to  claim 4 .  
     
     
         9 . A cosmetic formulation according to  claim 5 , where the formulation comprises one or more additional UV filters and/or antioxidants.  
     
     
         10 . A cosmetic formulation according to  claim 6 , where the formulation comprises one or more additional UV filters and/or antioxidants.  
     
     
         11 . A method for protecting the body's cells of a patient against oxidative stress, in particular for reducing skin ageing, comprising administering to said patient a formulation according to  claim 5 .  
     
     
         12 . A method for protecting the body's cells of a patient against oxidative stress, in particular for reducing skin ageing, comprising administering to said patient a formulation according to  claim 6 .  
     
     
         13 . An enriched foodstuff comprising a foodstuff and at least one compound according to  claim 1 .  
     
     
         14 . An enriched foodstuff comprising a foodstuff and at least one compound according to  claim 2 .  
     
     
         15 . A compound according to  claim 1  as medicaments.  
     
     
         16 . A compound according to  claim 2  as medicaments.  
     
     
         17 . Use of a compound according to  claim 2  for the preparation of a medicament against oxidative stress, in particular for reducing skin ageing.  
     
     
         18 . Use of a compound according to  claim 2  for the preparation of a medicament for the treatment of inflammations or allergic reactions.  
     
     
         19 . Use of a compound according to  claim 2  as antioxidant, in particular for cosmetic formulations.  
     
     
         20 . Use of compounds according to  claim 2  for the stabilization of UV filters, in particular dibenzoylmethane and derivatives of dibenzoylmethane.