US2002099181A1PendingUtilityA1

Anti-fibroblast growth factor-8 monoclonal antibody

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Assignee: KYOWA HAKKO KOGYO KKPriority: Apr 3, 1996Filed: Jun 8, 2001Published: Jul 25, 2002
Est. expiryApr 3, 2016(expired)· nominal 20-yr term from priority
Inventors:Nobuo HanaiMotoo YamasakiAkiko FuruyaAkira Tanaka
C23C 14/30A61P 35/00C07K 16/22C07K 2317/73C23C 26/00
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Claims

Abstract

Described is a monoclonal antibody capable of specifically binding to fibroblast growth factor-8 (FGF-8) which is related to growth factors of hormone-dependent tumor cells such as prostatic cancer and breast cancer, and inhibits the FGF-8 activity. The monoclonal antibody is useful in analyzing the role and biological function of FGF-8 in hormone-dependent tumor cells such as prostatic cancer and breast cancer and can be beneficial in the treatment of these cancers.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A monoclonal antibody which specifically binds to fibroblast growth factor-8 and inhibits activity of fibroblast growth factor-8.  
     
     
         2 . A monoclonal antibody KM1334 of the IgG1 subclass produced by hybridoma FERM BP-5451.  
     
     
         3 . A hybridoma FERM BP-5451 which produces a monoclonal antibody specifically binding to fibroblast growth factor-8.  
     
     
         4 . A method for immunologically detecting fibroblast growth factor-8 using the monoclonal antibody of claim  1 .

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