US2002098580A1PendingUtilityA1

MDM interacting protein and methods of use thereof

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Assignee: CURAGEN CORPPriority: Feb 23, 1999Filed: Jan 25, 2002Published: Jul 25, 2002
Est. expiryFeb 23, 2019(expired)· nominal 20-yr term from priority
Inventors:Krishnan NandabalanMeijia YangVincent Peter Schulz
A61P 35/00C07K 14/47A61P 43/00C07K 2319/00
45
PatentIndex Score
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Cited by
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References
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Claims

Abstract

Disclosed are complexes of the MDM2 protein and a novel MDM2-interacting protein (MDMIP). Also disclosed are nucleic acids encoding the MDMIP polypeptide, as well as derivatives, fragments, analogs and homologs of the MDMIP polypeptide and MDM2-MDMIP complexes.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A purified complex comprising an MDMIP binding domain of an MDM2polypeptide and an MDM2 binding domain of an MDMIP polypeptide.  
     
     
         2 . The complex of  claim 1 , wherein the MDMIP binding domain of the MDM2 polypeptide is present in a polypeptide comprising the amino acid sequence of an MDMIP polypeptide.  
     
     
         3 . The complex of  claim 1 , wherein the MDM2 binding domain of the MDMIP polypeptide is present in a polypeptide comprising the amino acid sequence of an MDMIP polypeptide.  
     
     
         4 . The complex of  claim 3 , wherein the MDMIP binding domain of the MDM2 polypeptide is present in a polypeptide comprising the amino acid sequence of an MDMIP polypeptide.  
     
     
         5 . The complex of  claim 1 , wherein the MDM2 polypeptide is a human MDM2 polypeptide.  
     
     
         6 . The complex of  claim 5 , wherein the MDMIP polypeptide is a human MDMIP polypeptide.  
     
     
         7 . The complex of  claim 1 , wherein the MDMIP polypeptide is a human MDMIP polypeptide.  
     
     
         8 . The complex of  claim 1 , wherein the MDMIP binding domain comprises a sequence that is at least 90% identical to the amino acid sequence of a region of an MDMIP polypeptide comprising the amino acid sequence of SEQ ID NO:  2 .  
     
     
         9 . The complex of  claim 1 , wherein the MDMIP polypeptide comprises a sequence that is at least 95% identical to the amino acid sequence of a human MDMIP polypeptide including the amino acid sequence of SEQ ID NO:  2 .  
     
     
         10 . The complex of  claim 1 , wherein the MDMIP polypeptide comprises the amino acid sequence of SEQ ID NO:  2 .  
     
     
         11 . The complex of  claim 10 , wherein the MDM2 polypeptide comprises the amino acid sequence of SEQ ID NO:  4 .  
     
     
         12 . The complex of  claim 1 , wherein the MDM2 polypeptide comprises the amino acid sequence of SEQ ID NO:  4 .  
     
     
         13 . The complex of  claim 1 , wherein the polypeptide comprising the MDMIP binding domain is labeled.  
     
     
         14 . The complex of  claim 1 , wherein the polypeptide comprising the MDM2 domain is labeled.  
     
     
         15 . The complex of  claim 1 , wherein the MDM2-binding domain of the MDMIP polypeptide is a fragment of an MDMIP polypeptide.  
     
     
         16 . The complex of  claim 1 , wherein the MDMIP binding domain of the MDM2 polypeptide is a fragment of an MDM2 polypeptide.  
     
     
         17 . A chimeric polypeptide comprising six or more amino acids of an MDM2 polypeptide covalently linked to six or more amino acids of an MDMIP polypeptide.  
     
     
         18 . The chimeric polypeptide of  claim 17 , wherein the amino acids of the MDM2 polypeptide comprise an MDMIP-binding domain.  
     
     
         19 . The chimeric polypeptide of  claim 17 , wherein the amino acids of the MDMIP polypeptide comprise an MDM2-binding domain.  
     
     
         20 . The chimeric polypeptide of  claim 17 , wherein the MDM2 binding domain comprises an amino acid sequence at lest 90% identical to the amino acid sequence of SEQ ID NO:  2 .  
     
     
         21 . A pharmaceutical composition comprising the complex of  claim 1.

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