US2002091271A1PendingUtilityA1

Process for the preparation of an indole derivative

Assignee: SMITHKLINE BEECHAM PLCPriority: Jul 16, 1998Filed: Mar 8, 2002Published: Jul 11, 2002

Est. expiryJul 16, 2018(expired)· nominal 20-yr term from priority

Inventors:Michael Fedouloff John Bryce Strachan

C07D 209/42

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References

Claims

Abstract

A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.

Claims

exact text as granted — not AI-modified

1 . A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a compound of formula (C)  
       
         
           
           
               
               
           
         
       
       with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.  
     
     
         2 . A process as claimed in  claim 1  in which the acid is trichloroacetic acid.

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