Antipsoriatic nail polish

Abstract

This invention relates to a nail polish comprising one or more glucocorticoids useful in treating nails which show changes due to the syndrome of psoriasis.

We claim:  
     
         1 . A nail polish comprising one or more glucocorticoids, one or more physiologically tolerable solvents and one or more water-insoluble film-forming agents.  
     
     
         2 . A nail polish according to  claim 1 , which comprises, as a glucocorticoid, alclometasone dipropionate, amcinonide, beclomethasone dipropionate, bendacort, betamethasone benzoate, betamethasone dipropionate, betamethasone valerate, budesonide, chlorquinaldol, clioquinol, clobetasol propionate, clobetasone butyrate, desonide, desoximetasone, dexamethasone, dichlorisone, diflorasone diacetate, diflucortolone valerate, difluprednate, fluazacort, flucinolone acetonide, fluclorolone acetonide, fludroxycortide, flumethasone pivalate, fluocinolone acetonide, fluocinonide, fluocortolone, fluorometholone, flupamesone, fluprednidene, fluprednidene acetate, flurandrenolide, halcinonide, halometasone, hydrocortamate, hydrocortisone butyrate, methylprednisolone aceponate, mometasone furoate, prednicarbate, prednisolone, prednisone, tixocortol, or triamcinolone acetonide.  
     
     
         3 . A nail polish according to  claim 1 , which comprises, as a glucocorticoid, clobetasol propionate, desoximetasone, betamethasone dipropionate, prednicarbate or halcinonide.  
     
     
         4 . A nail polish according to  claim 1 , which comprises one more glucocorticoids in a total concentration of 0.5% to 20% by weight.  
     
     
         5 . A nail polish according to  claim 1 , which comprises one or more glucocorticoids in a total concentration of 2% to 15% by weight.  
     
     
         6 . A nail polish according to  claim 1 , where the glucocorticoids are in the form of free alcohols or esters.  
     
     
         7 . A nail polish according to  claim 1 , wherein the content of glucocorticoid is at least 8% by weight.  
     
     
         8 . A nail polish according to  claim 1  wherein the glucocorticoid is present in the amount of about 1% to about 4% by weight.  
     
     
         9 . A nail polish according to  claim 1 , where the water-insoluble film-forming agent comprises a cellulose derivative.  
     
     
         10 . A nail polish according to  claim 9 , where the water-insoluble film-forming agent comprises cellulose nitrate, ethylcellulose, or mixtures thereof.  
     
     
         11 . A nail polish according to  claim 1 , where the water-insoluble film-forming agent comprises physiologically acceptable polymers.  
     
     
         12 . A nail polish according to  claim 1 , where the water-insoluble film-forming agent comprises a poly(vinyl acetate), partially hydrolyzed poly(vinyl acetate); copolymers of vinyl acetate with acrylic acid, or crotonic acid or monoalkyl maleate; ternary polymers of vinyl acetate with crotonic acid and vinyl neodecanoate; ternary polymers of vinyl acetate with crotonic acid and vinyl propionate; copolymers of methyl ethyl vinyl ether and monoalkyl maleates; copolymers of fatty acid vinyl esters and acrylic acid or methacrylic acid; copolymers of N-vinylpyrrolidone, methacrylic acid, and alkyl methacrylates; copolymers of acrylic acid and methacrylic acid, alkyl acrylates, or alkyl methacrylates.  
     
     
         13 . A nail polish according to  claim 12 , where the water-insoluble film-forming agent is a copolymer of methyl vinyl ether and monobutyl maleate.  
     
     
         14 . A nail polish according to  claim 12 , where the water-insoluble film-forming agent contains a quaternary ammonium group.  
     
     
         15 . A nail polish according to  claim 1 , where the water-insoluble film-forming agent comprises a polymer, copolymer, or mixture comprising one or more of ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride, polyvinyl acetals, polyvinyl butyrals, alkyl-substituted poly-N-vinylpyrrolidone, alkyl esters of copolymers of olefins and maleic anhydride, reaction products of colophony with acrylic acid, and benzoins.  
     
     
         16 . A nail polish according to  claim 1  where the water-insoluble film-forming agent comprises ethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate chloride in a molar ratio of 1:2:0.2.  
     
     
         17 . A nail polish according to  claim 1 , where the physiologically tolerable solvent comprises hydrocarbons, halogenated hydrocarbons, alcohols, ethers, ketones, esters, and mixtures thereof.  
     
     
         18 . A nail polish according to  claim 17 , where the physiologically tolerable solvent comprises acetate esters of monohydric alcohols.  
     
     
         19 . A nail polish according to  claim 18 , where the physiologically tolerable solvent comprises ethyl acetate, butyl acetate, mixtures thereof, mixtures with aromatic hydrocarbons, and mixtures with alcohols.  
     
     
         20 . A nail polish according to  claim 19  where the aromatic hydrocarbon is toluene.  
     
     
         21 . A nail polish according to  claim 19  where the alcohols comprise ethanol, isopropanol, or a mixture thereof.  
     
     
         22 . A nail polish according to  claim 1 , further comprising as an additive a plasticizer based on phthalate or camphor, a colorant or color pigment, pearl luster agents, sedimentation retardants, sulfonamide resins, silicates, aromatic substances, lanolin derivatives, sunscreens, antimicrobial substances, and substances having keratolytic activity, keratoplastic activity, or both, or mixtures thereof.  
     
     
         23 . A nail polish according to  claim 22 , where the additive sunscreen is 2-hydroxy-4-methoxybenzophenone.  
     
     
         24 . A nail polish according to  claim 22 , where the additive having keratolyitc activity, keratoplastic activity, or both is ammonium sulfite, esters and salts of thioglycolic acid, urea, allantoin, enzymes, and salicylic acid, and mixtures thereof.  
     
     
         25 . A method for preventing psoriasis of nails, comprising applying an effective amount of a nail polish according to  claim 1  to a nail of a host.