Mammalian alpha helical protein-1

Abstract

Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

We claim:  
     
         1 . An isolated polynucleotide which encodes a mammalian polypeptide, said polypeptide being comprised of amino acid sequence defined by SEQ ID NO:45 or an amino acid sequence which is at least 90% identical to SEQ ID NO:45.  
     
     
         2 . The polynucleotide of  claim 1  wherein said polynucleotide is an RNA.  
     
     
         3 . An isolated polynucleotide according to  claim 1  wherein said polynucleotide is DNA.  
     
     
         4 . A vector comprising the following operably linked elements: 
 a transcription promoter;    a DNA segment encoding a mammalian polypeptide, said polypeptide being comprised of amino acid sequence defined by SEQ ID NO:45    a transcription terminator.    
     
     
         5 . An isolated polypeptide comprised of a mammalian polypeptide, said polypeptide being comprised of an amino acid sequence defined by SEQ ID NO:45 or a polypeptide which is at least 90% identical to SEQ ID NO:45.  
     
     
         6 . A polypeptide according to  claim 6  further comprising a second polypeptide or protein.  
     
     
         7 . An antibody that specifically binds to a mammalian polypeptide, said polypeptide being comprised of SEQ ID NO:45 or polypeptide which is at least 90% identical to SEQ ID NO:45.  
     
     
         8 . An anti-idiotypic antibody of an antibody which specifically binds to a mammalian polypeptide said mammalian polypeptide being comprised of SEQ ID NO:45 or a polypeptide which is at least 90% identical to SEQ ID NO:45.  
     
     
         9 . A polypeptide which contains an amino acid sequence of an epitope-bearing portion of SEQ ID NO:45, said epitope-bearing portion having at least 30 amino acid residues of SEQ ID NO:45.  
     
     
         10 . An epitope-bearing polypeptide of  claim 9  wherein the polypeptide is selected from the group consisting of SEQ ID NO: 50, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55 and SEQ ID NO:56 or wherein the polypeptide is at least 90% identical to a polypeptide selected from the group consisting of SEQ ID NO: 50, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55 and SEQ ID NO:56.