Disulfide core polypeptides

Abstract

The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.

What is claimed is:  
     
         1 . An isolated polypeptide comprised of the amino acid sequence of SEQ ID NO:2, or SEQ ID NO:3.  
     
     
         2 . A isolated polypeptide comprised of an amino acid sequence of SEQ ID NO:5.  
     
     
         3 . An isolated polynucleotide which is at least 90% homologous to a polynucleotide which encodes a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO:3 and SEQ ID NO:5.  
     
     
         4 . The isolated polynucleotide of  claim 3  wherein the polynucleotide encodes a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO:3 and SEQ ID NO:5.  
     
     
         5 . An antibody which binds specifically to a polypeptide selected from the group consisting of SEQ ID NO: 2, SEQ ID NO:3 and SEQ ID NO:5.  
     
     
         6 . An anti-idiotypic antibody which binds to and neutralizes an antibody which binds specifically to a polypeptide selected from the group consisting of SEQ ID NO: 2, SEQ ID NO:3 and SEQ ID NO:5.  
     
     
         7 . An expression vector which contains a polynucleotide which encodes a polypeptide selected from the group consisting of SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:5.