Vitamin D derivative having substituent at 2beta-position

Abstract

A steroid intermediate has the formula (II): wherein A denotes alkylene of 2 to 10 carbons; X denotes halogen; R a , R b and R c denote, independently hydrogen or hydroxyl protecting group; and R p , R q , R y and R z are such that R p and R q together form a double bond between the 5-position and the 6-position and R y and R z together form a double bond between the 7-position and the 8-position, or R q and R y together form a double bond between the 6-position and the 7-position and R p and R z are bound to a dienophile capable of protecting conjugated double bonds.

What is claimed is:  
     
         1 . A steroid compound of the general formula (II)  
       
         
           
           
               
               
           
         
       
       wherein 
 A denotes a straight chain or branched chain alkylene group with 2 to 10 carbon atoms;  
 X denotes a halogen atom;  
 R a , R b  and R c  denote, independently of each other, a hydrogen atom or a hydroxyl group protecting group; and  
 R p , R q , R y  and R z  are such that 
 R p  and R q  together form a double bond between the 5-position and the 6-position and R y  and R z  together form a double bond between the 7-position and the 8-position or  
 R q  and R y  together form a double bond between the 6-position and the 7-position and R p  and R z  are bound to a dienophile capable of protecting conjugated double bonds.  
 
 
     
     
         2 . A steroid compound as claimed in  claim 1 , wherein A is a straight chain alkylene group with 2 to 10 carbon atoms; and X is an iodine atom.