Use of agonists or antagonists of P2 purinoceptors for the prevention glutamate-evoked cytotoxicity

Abstract

Compounds that are agonists of P2 purinoceptors, such as 5-adenylylimidodiphosphate, are used to treat conditions such as pain, hormonal imbalance, high blood pressure, thermoregulation, respiration, learning, patter recognition and memory.

1 . Compounds agonists of P2 purinoceptors for the prevention of glutamate-evoked cytotoxicity.  
     
     
         2 . Pharmacological composition comprising, as active ingredients, compounds agonists of P 2  purinoceptors, in addition to usual additives.  
     
     
         3 . Pharmacological composition according to  claim 2 , which comprises compounds agonists of P 2  purinoceptors as active agent, in addition to usual additives, in a pharmacologically acceptable means.  
     
     
         4 . Pharmacological composition according to  claim 2 , wherein said agonists of P 2  purinoceptors are 5-adenylylimidodiphosphate (AMPPNP).  
     
     
         5 . Method for the modulation of glutamate-evoked phisiological functions in a mammal in need thereof, which comprises administering to said mammal a pharmacological composition according to  claim 2 .  
     
     
         6 . Method according to  claim 5 , wherein said glutamate-evoked physiological functions are pain, hormonal balance, blood pressure, thermoregulation, respiration, learning, pattern recognition and memory.  
     
     
         7 . Method for the treatment of pain, hormonal balance, blood pressure, thermoregulation, respiration, learning, pattern recognition and memory in a mammal in need thereof, which comprises administering to said mammal a pharmacological composition according to  claim 2 .  
     
     
         8 . Method for the treatment of acute and chronic neurodegenerative diseases in a mammal in need thereof, which comprises administering to said mammal a pharmacological composition according to  claim 2 .  
     
     
         9 . Method for the prevention of glutamate-evoked neurotoxicity which comprises administering a pharmacological composition according to  claim 2 .  
     
     
         10 . Method for the treatment of pain, hormonal balance, blood pressure, thermoregulation, respiration, learning, pattern recognition and memory in a mammal in need thereof, which comprises administering to said mammal an effective amount of 5-adenylylimidodiphosphate (AMPPNP).