Diagnostic complex for measurement of the condition of biological tissues and liquids

Abstract

Disclosed is an assembly kit for an apparatus for simultaneously obtaining a biological sample and measuring the electrical resistance of said sample at at least two different frequencies for diagnosis of a condition of said sample. The assembly kit of the invention includes a main case; an aspirating needle adapted to be connected to the main case; a liquid collector adapted to be connected to said aspirating needle; and an electroimpedancemeter. The aspirating needle is used for obtaining a sample of biological liquid. The liquid collector receives said sample of said biological liquid and having a metal conductor in electrical contact with said needle and a metal piston. The electroimpedancemeter simultaneously measures electrical resistance of the sample at at least two different frequencies. Also disclosed is a method simultaneously obtaining a biological sample and measuring electrical impedance of the sample for the purpose of diagnosis of a condition of the sample. The method includes the steps of: contacting a biological tissue with an electrically conductive hook having a pointed end as a first electrode and a second electrode; measuring electrical impedance of the biological tissue contacted with the first and second electrodes at at least two different frequencies; and excising a part of the biological tissue with the pointed end of the hook to obtain a sample of the biological tissue.

What is claimed is:  
     
         1 . An assembly kit for an apparatus for simultaneously obtaining a biological sample and measuring the electrical resistance of said sample at at least two different frequencies for diagnosis of a condition of said sample, comprising: 
 a main case comprising a tube and demountable handle;    an aspirating needle adapted to be connected to the main case at least partially inside said tube, for obtaining a sample of biological liquid and for serving as an active electrode in contact with said biological sample;    a liquid collector adapted to be connected to said aspirating needle to receive said sample of said biological liquid, said liquid collector comprising a metal conductor in electrical contact with said needle and a metal piston, wherein at the determination of said condition of said biological liquid said needle executes the role of active electrode, and said metal piston executes the role of passive electrode; and    an electroimpedancemeter adapted to be electrically connected to said active and passive electrodes, for simultaneous measurement of said electrical resistance of the sample at at least two different frequencies.    
     
     
         2 . The assembly kit as defined in    claim 1   , further comprising a hook adapted to be attached to said tube, said hook comprising a pointed end for obtaining a sample of biological tissue, wherein at the determination of said condition of said biological tissue said needle executes the role of active electrode, and said hook executes the role of passive electrode.  
     
     
         3 . The assembly kit as defined in    claim 1   , wherein the main case has an electrical plug adapted to be electrically connected to each of said active and passive electrodes when assembled, wherein said electroimpedancemeter is electrically connected to said active and passive electrodes through the electrical plug.  
     
     
         4 . The assembly kit as defined in    claim 1   , wherein the electroimpedancemeter comprises a source of alternating current voltage consisting of two generators, one for a first frequency voltage and the other for a second frequency voltage, the second frequency is higher than the first frequency.  
     
     
         5 . The assembly kit as defined in    claim 4   , wherein the first frequency is in the range from about 0.5 to about 10 kHz.  
     
     
         6 . The assembly kit as defined in    claim 5   , wherein the first frequency is in the range from about 1 to about 5 kHz.  
     
     
         7 . The assembly kit as defined in    claim 6   , wherein the first frequency is in the range from about 1 to about 3 kHz.  
     
     
         8 . The assembly kit as defined in    claim 4   , wherein the second frequency is in the range from about 10 to about 1000 kHz.  
     
     
         9 . The assembly kit as defined in    claim 8   , wherein the second frequency is in the range from about 20 to about 500 kHz.  
     
     
         10 . The assembly kit as defined in    claim 9   , wherein the second frequency is in the range from about 50 to about 300 kHz.  
     
     
         11 . A method of simultaneously obtaining a biological sample and measuring electrical impedance of the sample for the purpose of diagnosis of a condition of the sample comprising: 
 contacting a biological tissue with an electrically conductive hook comprising a pointed end as a first electrode and a second electrode;    measuring electrical impedance of the biological tissue contacted with the first and second electrodes at at least two different frequencies; and    excising a part of the biological tissue with the pointed end of the hook to obtain a sample of the biological tissue.    
     
     
         12 . The method as defined in    claim 11   , wherein the second electrode comprises an aspirating needle connected to a syringe, the method further comprising: 
 inserting the aspirating needle into the biological tissue when contacting the biological tissue;    withdrawing a sample of biological liquid retained in the biological tissue into the syringe through the aspirating needle; and    measuring electrical impedance of the sampled biological liquid in the syringe at at least two different frequencies.    
     
     
         13 . The method as defined in    claim 11   , wherein the electrical impedance of the biological tissue or liquid is measured at a first and a second frequency.  
     
     
         14 . The method as defined in    claim 13   , wherein the first frequency is in the range from about 0.5 to about 10 kHz.  
     
     
         15 . The method as defined in    claim 14   , wherein the first frequency is in the range from about 1 to about 5 kHz.  
     
     
         16 . The method as defined in    claim 15   , wherein the first frequency is in the range from about 1 to about 3 kHz.  
     
     
         17 . The method as defined in    claim 13   , wherein the second frequency is in the range from about 10 to about 1000 kHz.  
     
     
         18 . The method as defined in    claim 17   , wherein the second frequency is in the range from about 20 to about 500 kHz.  
     
     
         19 . The method as defined in    claim 18   , wherein the second frequency is in the range from about 50 to about 300 kHz.