US2001031255A1PendingUtilityA1

Human hematopoietic progenitor cell preparations and their expansion in a liquid medium

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Priority: Apr 9, 1991Filed: May 16, 2001Published: Oct 18, 2001
Est. expiryApr 9, 2011(expired)· nominal 20-yr term from priority
Inventors:Ronald HoffmanJohn Brandt
C12N 2501/22C12N 2501/23C12N 2501/39C12N 2501/125C12N 5/0647C12N 2500/90
50
PatentIndex Score
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Cited by
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References
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Claims

Abstract

A process for supporting hematopoietic progenitor cells in a culture medium which contains at least one cytokine effective for supporting the cells and preferably, is essentially free of stromal cells.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A process for supporting mammalian bone marrow cells in a culture medium, which comprises: 
 maintaining bone marrow cells in a culture medium which is essentially free of stromal cells, said culture medium containing at least one cytokine effective for supporting said cells.    
     
     
         2 . A process as in    claim 1   , wherein said bone marrow cells are hematopoietic stem cells.  
     
     
         3 . A process as in    claim 1   , wherein said bone marrow cells are hematopoietic progenitor cells.  
     
     
         4 . A process as in    claim 1   , wherein said bone marrow cells are CD34 + DR − CD15 −  cells.  
     
     
         5 . A process as in    claim 1   , wherein at least one said cytokine is selected form the group consisting of IL-1; IL-3; IL-6; MGF; Fusion Protein of GM-CSF/IL-3.  
     
     
         6 . A process for supporting manmmalian bone marrow cells in a culture medium, which comprises: 
 maintaining bone marrow cells in a culture medium which contains a combination of cytokines effective for supporting said cells.    
     
     
         7 . A method acording to    claim 6   , wherein said culture medium is essentially free of stromal cells.  
     
     
         8 . A process as in    claim 6   , wherein said bone marrow cells are hematopoietic stem cells.  
     
     
         9 . A process as in    claim 6   , wherein said bone marrow cells are hematopoietic progenitor cells.  
     
     
         10 . A process as in    claim 6   , wherein said bone marrow cells are CD34 + DR − CD15 −  cells.  
     
     
         11 . A process as in    claim 6   , wherein at least one said cytokine is selected form the group consisting of IL-1; IL-3; IL-6; MGF; Fusion Protein of GM-CSF/IL3.

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