Emulsion preconcentrate comprising a cyclosporin and acetylated monoglyceride

Abstract

A pharmaceutical composition in the form of an emulsion preconcentrate comprising a cyclosporin dissolved in a solvent system comprising acetylated monoglycerides, a hydrophilic organic solvent and a surfactant.

What is claimed is:  
     
         1 . A pharmaceutical composition in the form of an emulsion preconcentrate comprising a cyclosporin dissolved in a solvent system comprising acetylated monoglycerides, a hydrophilic organic solvent and a surfactant.  
     
     
         2 . A composition as in    claim 1    in the form of a microemulsion preconcentrate.  
     
     
         3 . A composition as in    claim 1    or    2    wherein the acetylated monoglyceride is a fully acetylated monoglyceride prepared from unsaturated moncglyceride.  
     
     
         4 . A composition as in    claim 1    wherein the hydrophilic organic solvent is miscible with the acetylated monoglycerides.  
     
     
         5 . A composition as in    claim 1    wherein the hydrophilic organic solvent is selected from ethanol, propylene glycol, propylene carbonate, benzyl alcohol, and polyethylene glycol having mean molecular weight of less than about 1000.  
     
     
         6 . A composition as in    claim 5    wherein the hydrophilic organic solvent is ethanol.  
     
     
         7 . A composition as in    claim 5    wherein the hydrophilic organic solvent is propylene glycol.  
     
     
         8 . A composition as in    claim 5    wherein the hydrophilic organic solvent is propylene carbonate.  
     
     
         9 . A composition as in    claim 5    wherein the hydrophilic organic solvent is benzyl alcohol.  
     
     
         10 . A composition as in    claim 5    wherein the hydrophilic organic solvent is polyethylene glycol having mean molecular weight of less than about 1000.  
     
     
         11 . A composition as in any of    claims 1    to    10    wherein the surfactant is a polyoxyethylene glycolated natural or hydrogenated vegetable oil.  
     
     
         12 . A composition as in    claim 11    wherein the surfactant is polyoxyl 40 hydrogenated castor oil.  
     
     
         13 . A composition as in any of    claims 1    to    11    wherein the surfactant is a polyoxyethylene-sorbitan-fatty acid ester.  
     
     
         14 . A composition as in any of    claims 1    to    10    comprising two surfactants, one of which is a polyoxyethylene glycolated natural or hydrogenated vegetable oil and the second of which is a polyoxyethylene-sorbitan-fatty acid ester.