Virginiamycin mixture

Abstract

A mixture comprising: a) virginiamycin; b) a pharmaceutically acceptable and substantially anhydrous wetting agent including sodium lauryl sulfate; c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water; and d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide, wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1. The mixture is designed to be added to water to produce a stable suspension of the virginiamycin, which can then be applied to, for example, feed grain.

1 . A mixture comprising: 
 a) virginiamycin;    b) a pharmaceutically acceptable surfactant including sodium lauryl sulfate;    c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water; and    d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,    wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1.    
     
     
         2 . The mixture of    claim 1   , wherein the ratio of (b) to (a) is about 1.54:1.  
     
     
         3 . The mixture of    claim 1   , wherein the amount of buffer is sufficient to provide a pH of from about 4.0 to about 5.5 when said mixture is added to water.  
     
     
         4 . The mixture of    claim 1   , wherein said buffer includes citric acid and sodium citrate.  
     
     
         5 . The mixture of    claim 4   , wherein said citric acid and sodium citrate are substantially anhydrous.  
     
     
         6 . The mixture of    claim 1   , further including a pharmaceutically acceptable anti-foaming agent.  
     
     
         7 . The mixture of    claim 6   , wherein said anti-foaming agent is polydimethylsiloxane.  
     
     
         8 . The mixture of    claim 1   , further including a pharmaceutically acceptable dye.  
     
     
         9 . The mixture of    claim 1   , wherein said virginiamycin is substantially pure.  
     
     
         10 . The mixture of    claim 1   , wherein said mixture is substantially anhydrous.  
     
     
         11 . A substantially anhydrous mixture comprising: 
 a) virginiamycin;    b) a pharmaceutically acceptable and substantially anhydrous surfactant including sodium lauryl sulfate;    c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water; and    d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,    wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1.    
     
     
         12 . The anhydrous mixture of    claim 11   , wherein the ratio of (b) to (a) is about 1.54:1.  
     
     
         13 . The anhydrous mixture of    claim 11   , where the amount of buffer is sufficient to provide a pH of from about 4.0 to about 5.5 when said mixture is added to water.  
     
     
         14 . The anhydrous mixture of    claim 11   , wherein said buffer includes substantially anhydrous citric acid and substantially anhydrous sodium citrate.  
     
     
         15 . The anhydrous mixture of    claim 11   , further including a pharmaceutically acceptable anti-foaming agent.  
     
     
         16 . The anhydrous mixture of    claim 15   , wherein said anti-foaming agent is polydimethylsiloxane.  
     
     
         17 . The anhydrous mixture of    claim 11   , further including a pharmaceutically acceptable dye.  
     
     
         18 . The anhydrous mixture of    claim 11   , wherein said virginiamycin is substantially pure.  
     
     
         19 . A substantially anhydrous mixture comprising: 
 a) virginiamycin;    b) a pharmaceutically acceptable and substantially anhydrous surfactant including sodium lauryl sulfate;    c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water;    d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide;    e) a pharmaceutically acceptable anti-foaming agent; and    f) a pharmaceutically acceptable dye.    wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1.    
     
     
         20 . The anhydrous mixture of    claim 19   , wherein the ratio of (b) to (a) is about 1 54:1.  
     
     
         21 . The anhydrous mixture of    claim 19   , where the amount of buffer is sufficient to provide a pH of from about 4 0 to about 5.5 when said mixture is added to water.  
     
     
         22 . The anhydrous mixture of    claim 19   , wherein said buffer includes substantially anhydrous citric acid and substantially anhydrous sodium citrate.  
     
     
         23 . The anhydrous mixture of    claim 19   , wherein said anti-foaming agent is polydimethylsiloxane.  
     
     
         24 . The anhydrous mixture of    claim 19   , wherein said virginiamycin is substantially pure.  
     
     
         25 . Feed grain treated with a water suspension of a mixture comprising: 
 a) virginiamycin;    b) a pharmaceutically acceptable surfactant including sodium lauryl sulfate;    c) a sufficient amount of pharmaceutically acceptable buffering agent to maintain said suspension at a pH of from about 3.0 to about 7.0;    d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,    wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1.    
     
     
         26 . The feed grain of    claim 25   , wherein the ratio of (b) to (a) is about 1.54:1.  
     
     
         27 . The feed grain of    claim 25   , where the amount of buffer is sufficient to provide a pH of from about 4.0 to about 5.5 in said suspension.  
     
     
         28 . The feed grain of    claim 25   , wherein said buffer includes citric acid and sodium citrate.  
     
     
         29 . The feed grain of    claim 28   , wherein the citric acid and sodium citrate is substantially anhydrous.  
     
     
         30 . The feed grain of    claim 25   , said mixture further including a pharmaceutically acceptable dye.  
     
     
         31 . The feed grain of    claim 25   , wherein said virginiamycin is substantially pure.  
     
     
         32 . The feed grain of    claim 25   , further including a pharmaceutically acceptable anti-foaming agent in said mixture.  
     
     
         33 . The feed grain of    claim 32   , wherein said antifoaming agent is polydimethylsiloxane.  
     
     
         34 . A method of treating feed grain with virginiamycin, comprising 
 (1) forming a mixture including: 
 a) virginiamycin,  
 b) a pharmaceutically acceptable surfactant including sodium lauryl sulfate,  
 c) a sufficient amount of pharmaceutically acceptable buffering agent to provide a pH of from about 3.0 to about 7.0 when said mixture is added to water, and  
 d) from about 0.5 weight percent to about 10.0 weight percent colloidal silicon dioxide,  
 wherein the ratio of the weight percent of (b) to the weight percent of (a) percent by weight is at least about 1.5:1;  
   (2) suspending said mixture in water to form a suspension; and    (3) applying said suspension to feed grain.    
     
     
         35 . The method of    claim 34   , wherein the ratio of (b) to (a) in said mixture is about 1.54:1.  
     
     
         36 . The method of    claim 34   , wherein the amount of buffer in said mixture is sufficient to provide a pH of from about 4.0 to about 5.5 when said mixture is added to water.  
     
     
         37 . The method of    claim 34   , wherein said buffer in said mixture includes citric acid and sodium citrate.  
     
     
         38 . The method of    claim 37   , wherein said citric acid and sodium citrate are substantially anhydrous.  
     
     
         39 . The method of    claim 34   , further including a pharmaceutically acceptable anti-foaming agent in said mixture.  
     
     
         40 . The method of    claim 39   , wherein said anti-foaming agent is polydimethylsiloxane.  
     
     
         41 . The method of    claim 34   , further including a pharmaceutically acceptable dye in said mixture.  
     
     
         42 . The method of    claim 34   , wherein said virginiamycin in said mixture is substantially pure.  
     
     
         43 . The method of    claim 34   , wherein said mixture is substantially anhydrous.  
     
     
         44 . The method of    claim 34   , wherein said applying step includes spraying the feed grain with said suspension.  
     
     
         45 . The method of    claim 34   , further including drying the feed grain after the applying step.