Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained

Abstract

The invention concerns the use of a substance P antagonist in a cosmetic composition used to treat sensitive skin. More specifically, the invention relates to a substance P antagonist used to prevent and/or combat skin irritations, desquamation, erythemas, sensations of dysesthesia/overheating, or pruritus of the skin.

1 . Use of a substance P antagonist in a composition containing a cosmetically-acceptable medium for treatment of sensitive skin.  
     
     
         2 . Use according to    claim 1   , wherein the substance P antagonist is chosen among the peptides and compounds containing at least one nitrogenous heterocyclic compound.  
     
     
         3 . Use according to    claim 1    or    2   , wherein the peptide is sendide or spantide II.  
     
     
         4 . Use according to    claim 1    or    2   , wherein the compound containing at least one nitrogenous heterocyclic compound is a derivative of 2-tricyclyl-2-aminoethane, a derivative of spirolactame, a derivative of quinuclidine, an azacyclic derivative, a derivative of aminopyrrolidine, a derivative of piperidine, an aminoazaheterocyclic compound, or a derivative of isoindole.  
     
     
         5 . Use according to any of the preceding claims, wherein the substance P antagonist is used in a quantity of between 0.000001 to 5% by weight of the total weight of the composition.  
     
     
         6 . Use according to any of the preceding claims, wherein the substance P antagonist is used in a quantity of between 0.0001 to 0.1% of the total weight of the composition.  
     
     
         7 . Use according to any of the preceding claims, wherein the cosmetically-acceptable medium is an aqueous or hydroalcoholic solution, a water-in-oil or oil-in-water emulsion, a microemulsion, an aqueous gel, an anhydrous gel, a serum, or a vesicular dispersion.  
     
     
         8 . Use according to any of the preceding claims, wherein the composition contains at least one agent chosen from among antibacterial, anti-parasitical, anti-fungal, anti-inflammatory, anti-pruriginous, anesthetic, antiviral, keratolytic, anti-free radical, anti-seborrhea, dandruff-fighting, and acne-fighting agents and/or agents modulating skin differentiation, proliferation, and/or pigmentation.  
     
     
         9 . Use according to the preceding claim, wherein the agent is lidocaine chlorhydrate, or a non-steroid anti-parasitical or anti-inflammatory agent.  
     
     
         10 . Use in a cosmetic composition of a substance P antagonist to prevent and/or combat skin irritations, desquamation, erythemas, sensations of dysesthesia, sensations of overheating, and/or pruritis of the skin.  
     
     
         11 . Use according to    claim 10   , wherein the substance P antagonist is chosen from among peptides and compounds containing at least one nitrogenous heterocyclic compound.  
     
     
         12 . Use according to    claim 10    or    11   , wherein the substance P antagonist is used in a quantity of between 0.000001 and 5% by weight of the total weight of the composition.  
     
     
         13 . Use according to any of    claims 10    to    12   , wherein the substance P antagonist is used in a quantity of between 0.0001 and 0.1% by weight of the total weight of the composition.  
     
     
         14 . Cosmetic treatment process, wherein a composition containing a substance P antagonist in a cosmetically-acceptable medium is applied on the skin, hair, and/or mucous membranes.  
     
     
         15 . Process according to    claim 14   , wherein the substance P antagonist is chosen from among the peptides and compounds containing at least one nitrogenous heterocyclic compound.  
     
     
         16 . Process according to    claim 14    or    15   , wherein the substance P antagonist is used in a quantity of between 0.000001 to 5% by weight of the total weight of the composition.  
     
     
         17 . Process according to any of    claims 14    to    16   , wherein the substance P antagonist is used in a quantity of between 0.0001 and 0.1% by weight of the total weight of the composition.  
     
     
         18 . Cosmetic composition containing a cosmetically-acceptable medium and at least one active ingredient producing an irritant side effect, wherein said composition contains a substance P antagonist.  
     
     
         19 . Cosmetic composition according to    claim 18   , wherein the substance P antagonist is chosen from among the peptides and compounds containing at least one nitrogenous heterocyclic compound.  
     
     
         20 . Cosmetic composition according to    claim 18    or    19   , wherein the substance P antagonist is used in a quantity of between 0.000001 and 5% by weight of the total weight of the composition.  
     
     
         21 . Cosmetic composition according to any of    claims 18    to    20   , wherein the substance P antagonist is used in a quantity of between 0.0001 and 0.1% by weight of the total weight of the composition.  
     
     
         22 . Cosmetic composition according to any of    claims 18    to    21   , wherein the active ingredient producing an irritant side effect is chosen from among α-hydroxy acids, β-hydroxy acids, α-ketonic acids, β-ketonic acids, retinoids, anthralines, anthranoids, peroxides, minoxidil, lithium salts, antimetabolites, and vitamin D and the derivatives thereof.  
     
     
         23 . Cosmetic composition according to any of    claims 18    to    22   , wherein said cosmetic composition further contains at least one agent selected from among antibacterial, anti-parasitical, antifungal, anti-inflammatory, anti-pruriginous, anesthetic, antiviral, keratolytic, anti-free radical, anti-seborrhea, dandruff-fighting, and acne-fighting agents and/or agents modulating skin differentiation, proliferation, and/or pigmentation.  
     
     
         24 . Use of capsaicin for preparation of a composition intended to identify sensitive skin.