Compositions and methods of treating skin conditions

Abstract

A composition is described comprising a vitamin D analog and a retinoid, wherein: (a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and (b) the retinoid is selected from the group consisting of a compound capable of binding a retinoic acid receptor, retinol in a concentration of at least about 0.1% and a compound in a concentration of at least about 0.% capable of being converted in vivo into retinol. Further, methods of treating disorders characterized by abnormal cell-proliferation and/or cell-differentiation are also described.

What is claimed is:  
     
         1 . A composition comprising a vitamin D analog and a retinoid, wherein: 
 (a) the vitamin D analog is capable of binding a vitamin D receptor or being converted in vivo into a compound capable of binding a vitamin D receptor; and    (b) the retinoid is selected from the group consisting of a compound capable of binding a retinoic acid receptor, retinol in a concentration of at least about 0.1% and a compound in a concentration of at least about 0.1% capable of being converted in vivo into retinal.    
     
     
         2 . A topical composition according to    claim 1   .  
     
     
         3 . The composition of    claim 1   , wherein the vitamin D analog is selected from the group consisting of cholecalciferol, calcifediol, calcitriol, calcipotriol, ergocalciferol, dihydrotachysterol, 1,25-dihydroxyergocalciferol, and 25-hydroxydihydrotachysterol.  
     
     
         3 . The composition of    claim 1   , wherein the vitamin D analog is calcitriol.  
     
     
         4 . The composition of    claim 1   , wherein the vitamin D analog is calcipotriol.  
     
     
         5 . The composition of    claim 1   , wherein the retinoid is retinal.  
     
     
         6 . The composition of    claim 1   , wherein the retinoid is a retinyl ester.  
     
     
         7 . The composition of    claim 1   , wherein the vitamin D analog is calcitriol or calcipotriol at a concentration of about 0.005% and the retinoid is a retinyl ester at a concentration of about 5%.  
     
     
         8 . The composition of    claim 6   , wherein the retinyl ester is retinyl palmitate.  
     
     
         9 . The composition of    claim 1   , wherein the retinoid is retinal.  
     
     
         10 . A method of treating a subject suffering from a disorder characterized by abnormal cell-proliferation and/or cell-differentiation, in which a composition according to    claim 1    is administered to the subject in need of such treatment.  
     
     
         11 . A method of treating a subject suffering from a disorder selected from the group consisting of psoriasis, acne, eczema, rosacea, actinic keratosis, seborrheic dermatitis, and congenital keratinization disorders, in which a composition according to    claim 1    is administered to the subject in need of such treatment.  
     
     
         12 . The method of    claim 11   , wherein the disorder is psoriasis.  
     
     
         13 . The method of    claim 11   , wherein the disorder is eczema.  
     
     
         14 . The method of    claim 11   , wherein the disorder is acne.  
     
     
         15 . A method of treating one or more conditions of the skin selected from the group consisting of dry skin, photodamaged skin, age spots, aged skin, increasing stratum corneum flexibility, wrinkles, fine lines, actinic blemishes, skin dyschromias, and ichthyosis, comprising applying to the skin having said one or more condition the composition of    claim 1   .  
     
     
         16 . A composition comprising retinol in a concentration of at least about 1.5% or a compound in a concentration of at least about 1.5% capable of being converted in vivo into retinol.  
     
     
         17 . A method of treating one or more conditions of the skin selected from the group consisting of dry skin, photodamaged skin, age spots, aged skin, increasing stratum corneum flexibility, wrinkles, fine lines, actinic blemishes, skin dyschromias, ichthyosis and acne, comprising applying to the skin having said one or more condition the composition of    claim 16   .  
     
     
         18 . The method of    claim 17   , wherein the skin condition is acne.  
     
     
         19 . The method of    claim 17   , wherein the skin condition is actinic blemishes.  
     
     
         20 . The method of    claim 16   , wherein the skin condition is fine wrinkles.