Compositions and methods for modulating inflammatory and degenerative disorder

Abstract

The disclosure provides compounds and method useful for modulating gp130 biological activity. The disclosure also provides methods and compositions for treating disease and disorders associated with gp130 activity, particularly those associated with inflammation.

What is claimed is: 
     
         1 . A method of treating osteoarthritis comprising injecting into a joint space of a human subject a therapeutically effective amount of microspheres containing compound 805: 
       
         
           
           
               
               
           
         
       
     
     
         2 . The method of  claim 1 , wherein the microspheres further comprises hyaluronic acid. 
     
     
         3 . The method of  claim 1 , further comprising contacting the human subject with an additional therapeutic compound selected from the group consisting of glucocorticoid treatments, steroidals, local or general anesthetics, NSAIDS, low molecular weight heparins, anti-inflammatoireanti-TNF antibodies and soluble TNF receptors and cyclooxygenase-2 inhibitors. 
     
     
         4 . The method of  claim 1 , wherein compound 805 is present at a concentration less than about 10 mg/kg of body weight. 
     
     
         5 . The method of  claim 1 , wherein the microspheres are sterilized by filtration. 
     
     
         6 . The method of  claim 1 , wherein the microspheres are formulated for injection into a knee or hip.