Composition comprising at least one enzyme and at least one microbicidal molecule for the prevention or treatment of post-implant infections

Abstract

The present invention relates to a composition comprising at least one enzyme and at least one microbicidal molecule as combination products, for simultaneous use, separated use or use staggered over time, for use in the preventative and/or curative treatment of infections at an implant site, said infections being post-implant infections of mammalian bodies, in particular post-implant infections of the human body.

The invention claimed is: 
     
       1. A method of treatment for post-implantation infections of mammalian bodies, the method comprising:
 administering a therapeutically effective amount of a composition comprising a combination of an enzymatic cocktail of Dispersin B, cellulase, and DNase; and a fluoroquinolone microbicidal molecule, wherein the composition is sterile, and wherein the composition is effective to reduce by at least 1 Log 10 the number of viable bacteria in biofilms formed post-implantation by bacteria species selected from the species group consisting of  Staphylococcus aureus  to a mammalian body following implantation of an implantable medical device, the mammalian body being subject to post-implantation infection by bacteria belonging to the species  Staphylococcus aureus.