Polypeptides having anti-senescent effects and uses thereof

Abstract

Polypeptides which can provide a senotherapeutic effect are provided herein. The polypeptides can be formulated for topical application and can be applied topically to a subject to provide a senotherapeutic effect in the subject or in the cells of the subject.

What is claimed is: 
     
       1. A composition comprising a polypeptide comprising an amino acid sequence selected from a group consisting of ETAKHWLKGI (SEQ ID NO: 1), ATAKAWLKGI (SEQ ID NO:2), KLKGILRGAA (SEQ ID NO:3), and WLKGILREAA (SEQ ID NO: 4). 
     
     
       2. The composition of  claim 1 , wherein the polypeptide comprises at least 10 amino acids, 15 amino acids, or 20 amino acids. 
     
     
       3. The composition of  claim 1 , wherein the composition is formulated for application to skin. 
     
     
       4. The composition of  claim 3 , wherein the composition is a cream, a transdermal patch, a topical patch, an ointment, an oil, a gel, a liquid, a powder, a lotion, a serum, an emulsion, a moisturizer, a foam, a face mask, a mousse, an aerosol, a spray, a cleanser, a toner, or a shampoo. 
     
     
       5. The composition of  claim 1 , wherein the composition further comprises a UV blocker. 
     
     
       6. The composition of  claim 5 , wherein the UV blocker comprises at least one of aminobenzoic acid, avobenzone, cinoxate, dioxybenzone, homosalate, meradimate, octocrylene, octinoxate, octisalate, oxybenzone, padimate O, ensulizole, sulisobenzone, titanium dioxide, trolamine salicylate, or zinc oxide. 
     
     
       7. The composition of  claim 1 , wherein the composition comprises at least one emollient selected from a group consisting of plant oil, mineral oil, shea butter, cocoa butter, petrolatum, fatty acid, triglyceride, benzoate, myristate, palmitates, stearates, glycolipids, phospholipids, squalene, glycerin, ceramide, and algae extract. 
     
     
       8. The composition of  claim 7 , wherein the plant oil comprises at least one of jojoba oil, rose hip oil, andiroba oil, grape seed oil, avocado oil, plum seed oil, pracaxi oil,  Calycophyllum spruceanum  oil, almond oil, or argan oil. 
     
     
       9. The composition of  claim 1 , wherein the composition comprises at least one skin hydrating agent selected from a group consisting of glycerin, squalene, sorbitol, hyaluronic acid, hyaluronic acid derivative, sodium hyaluronate, sodium hyaluronate crosspolymer, niacinamide, glycoprotein, pyrrolidone carboxylic acid (PCA), lysine HCl, allantoin, and algae extract. 
     
     
       10. The composition of  claim 1 , wherein the composition comprises at least one vitamin selected from a group consisting of vitamin A, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B7 (biotin), vitamin B6, vitamin B 12 (cyanocobalamin), vitamin B9, folic acid, niacinamide, and derivatives thereof. 
     
     
       11. The composition of  claim 1 , wherein the composition comprises an amount of the polypeptide of about 500 nM to about 500 μM. 
     
     
       12. The composition of  claim 1 , wherein the composition comprises an amount of the polypeptide of about 0.001% to about 5% (w/w). 
     
     
       13. The composition of  claim 1 , wherein the amino acid sequence is ETAKHWLKGI (SEQ ID NO:1). 
     
     
       14. The composition of  claim 1 , wherein the amino acid sequence is ATAKAWLKGI (SEQ ID NO:2).