Compositions and methods for treating, preventing or reversing age associated inflammation and disorders

Abstract

Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).

What is claimed is: 
     
       1. A method for slowing down the progression of and/or lessening the symptoms of Alzheimer's disease, amyotrophic lateral sclerosis, autism spectrum disorder, dementia with Lewy Bodies, frontotemporal dementia, mild cognitive impairment, Parkinson's disease, progressive supra nuclear palsy, Rett Syndrome, or Aicardi-Goutieres syndrome in a patient in need thereof, the method comprising administering a therapeutically effective amount of censavudine to the patient. 
     
     
       2. The method of  claim 1  comprising administering about 1 μg/kg to about 100 mg/kg of censavudine to the patient per day. 
     
     
       3. The method of  claim 2  comprising administering about 1 mg/kg to about 50 mg/kg of censavudine to the patient per day. 
     
     
       4. The method of  claim 3  comprising administering about 5 mg/kg of censavudine to the patient per day. 
     
     
       5. The method of  claim 3  comprising administering about 10 mg/kg of censavudine to the patient per day. 
     
     
       6. The method of  claim 3  comprising administering about 15 mg/kg of censavudine to the patient per day. 
     
     
       7. The method of  claim 3  comprising administering about 20 mg/kg of censavudine to the patient per day. 
     
     
       8. The method of  claim 1  comprising administering 1 mg to 500 mg of censavudine to the patient once a day, twice a day, or three times a day. 
     
     
       9. The method of  claim 8  comprising administering 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg, 80 mg, 90 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, or 150 mg of censavudine to the patient once a day, twice a day, or three times a day. 
     
     
       10. The method of  claim 1 , wherein the censavudine is orally administered to the patient in the form of a tablet, capsule, or suspension. 
     
     
       11. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of Alzheimer's disease. 
     
     
       12. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of amyotrophic lateral sclerosis. 
     
     
       13. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of autism spectrum disorder. 
     
     
       14. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of dementia with Lewy Bodies. 
     
     
       15. The method of  claim 1  for curing, slowing down the progression of and/or lessening the symptoms of frontotemporal dementia. 
     
     
       16. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of mild cognitive impairment. 
     
     
       17. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of Parkinson's disease. 
     
     
       18. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of progressive supra nuclear palsy. 
     
     
       19. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of Rett Syndrome. 
     
     
       20. The method of  claim 1  slowing down the progression of and/or lessening the symptoms of Aicardi-Goutieres syndrome.