Anti-dandruff composition

Abstract

Described herein is an anti-dandruff composition including at least two anti-dandruff actives selected from a punicalagin composition; a first monoterpenoid composition, or a second monoterpenoid composition; and a dermatologically-acceptable carrier. The two or more anti-dandruff actives are present in the anti-dandruff composition in an effective amount to treat or prevent dandruff caused by the proliferation of Malassezia furfur.

The invention claimed is: 
     
       1. An anti-dandruff composition comprising:
 a combination of anti-dandruff actives, said anti-dandruff actives comprising:
 a punicalagin composition, 
 a first monoterpenoid composition comprising p-cymene, 
 a second monoterpenoid composition comprising menthol; and 
 
 a dermatologically-acceptable carrier; 
 wherein the combination of anti-dandruff actives is present in the anti-dandruff composition in an amount effective to inhibit a proliferation of  Malassezia furfur  and thereby treat dandruff; and wherein the first monoterpenoid composition further comprises thymol and gamma-terpinene. 
 
     
     
       2. The anti-dandruff composition of  claim 1 , wherein the second monoterpenoid composition further comprises menthone, isomenthone, menthyl acetate, neomenthol, limonene, or combinations thereof. 
     
     
       3. The anti-dandruff composition of  claim 1 , wherein the punicalagin composition is derived from extracting pomegranate rind with an aqueous extraction liquid comprising water or an aqueous alcoholic solution. 
     
     
       4. The anti-dandruff composition of  claim 1 , wherein the punicalagin composition comprises a polyphenol content of at least 30 gallic acid equivalents (GAE), on a dry weight basis. 
     
     
       5. The anti-dandruff composition of  claim 1 , wherein the punicalagin composition comprises punicalagin A, punicalagin B, or both in 0.1 wt % or more, based on a dry weight basis. 
     
     
       6. The anti-dandruff composition of  claim 1 , wherein the punicalagin composition comprises less than 5 wt % ellagic acid, based on a dry weight basis. 
     
     
       7. The anti-dandruff composition of  claim 1 , wherein the first monoterpenoid composition is obtained from an ajowan essential oil. 
     
     
       8. The anti-dandruff composition of  claim 1 , wherein the second monoterpenoid composition is obtained from a corn mint essential oil. 
     
     
       9. The anti-dandruff composition of  claim 1 , wherein the first monoterpenoid composition is present in an amount in a range from 0.1 wt % to 5 wt % based on the entire weight of the composition. 
     
     
       10. The anti-dandruff composition of  claim 1 , wherein the punicalagin composition is present in an amount in a range from 0.1 wt % to 10 wt % based on the total weight of the anti-dandruff composition. 
     
     
       11. The anti-dandruff composition of  claim 1 , wherein the second monoterpenoid composition is present in an amount in a range from 0.25 wt % to 10 wt % based on the total weight of the anti-dandruff composition. 
     
     
       12. The anti-dandruff composition of  claim 1 ,
 wherein the punicalagin composition is present in an amount in a range from 0.1 wt % to 10 wt %; 
 wherein the first monoterpenoid composition is present in an amount in a range from 0.1 wt % to 5 wt %; 
 wherein the second monoterpenoid composition is present in an amount in a range from 0.25 wt % to 10 wt %; 
 wherein the dermatologically-acceptable carrier comprises water and a detersive surfactant; and 
 wherein the wt % is based on the total weight of the anti-dandruff composition. 
 
     
     
       13. The anti-dandruff composition of  claim 12 , wherein the dermatologically-acceptable carrier comprising water and the detersive surfactant is present in a range from about 30 wt % to about 99 wt %, based on the total weight of the anti-dandruff composition. 
     
     
       14. A method of treating a subject having dandruff dandruff symptoms associated with a proliferation of  Malassezia furfur  on a scalp of the subject, comprising:
 contacting the subject's scalp or keratinous tissue with an effective quantity of the anti-dandruff composition of  claim 1 . 
 
     
     
       15. The method of  claim 14 , further comprising massaging onto the scalp the anti-dandruff composition; and maintaining the anti-dandruff composition in contact with the subject's scalp or keratinous tissue for a duration of at least 15 seconds or more. 
     
     
       16. The method of  claim 15 , further comprising rinsing out the anti-dandruff composition. 
     
     
       17. The method of  claim 14 , wherein the punicalagin composition is present in the anti-dandruff composition an amount in a range from 0.1 wt % to 10 wt %;
 wherein the first monoterpenoid composition is present in an amount in a range from 0.1 wt % to 5 wt %; 
 wherein the second monoterpenoid composition is present in an amount in a range from 0.25 wt % to 10 wt %; 
 wherein the dermatologically-acceptable carrier comprises water and a detersive surfactant; and 
 wherein the wt % is based on the total weight of the anti-dandruff composition. 
 
     
     
       18. The method of  claim 17 , wherein the punicalagin composition is derived from extracting pomegranate rind with an aqueous extraction liquid comprising water or an aqueous alcoholic solution; wherein the second monoterpenoid composition further comprises menthone, isomenthone, menthyl acetate, neomenthol, limonene, or combinations thereof. 
     
     
       19. The method of  claim 14 , wherein, based on a dry weight basis, the punicalagin composition comprises punicalagin A, punicalagin B, or both in 0.1 wt % or more; and wherein the punicalagin composition comprises less than 5 wt % ellagic acid. 
     
     
       20. The anti-dandruff composition of  claim 1 , wherein the p-cymene is present in the first monoterpenoid composition in an amount of at least 20 wt %, based on the weight of the first monoterpenoid composition. 
     
     
       21. The anti-dandruff composition of  claim 1 , wherein the first monoterpenoid composition comprises 20-60 wt % gamma-terpinene, 20-60 wt % p-cymene, and 20-60 wt % thymol, based on the weight of the first monoterpenoid composition. 
     
     
       22. The anti-dandruff composition of  claim 1 , wherein a combined mass of the gamma-terpinene, p-cymene, and thymol constitute at least 80 wt % of the first monoterpenoid composition. 
     
     
       23. An anti-dandruff composition comprising:
 a combination of anti-dandruff actives, said anti-dandruff actives comprising:
 a punicalagin composition, 
 a first monoterpenoid composition comprising p-cymene, 
 a second monoterpenoid composition comprising menthol; and 
 
 a dermatologically-acceptable carrier; 
 
       wherein the combination of anti-dandruff actives is present in the anti-dandruff composition in an amount effective to inhibit a proliferation of  Malassezia furfur  and thereby treat dandruff; wherein the first monoterpenoid composition further comprises thymol and gamma-terpinene; and 
       wherein the second monoterpenoid composition further comprises menthone, isomenthone, menthyl acetate, neomenthol, limonene, or combinations thereof.