Composition for preventing or treating mental disorder, containing Lactobacillus sp. bacteria-derived vesicle

Abstract

The present invention relates to a composition for preventing, improving or treating a mental disorder, the composition containing a Lactobacillus sp. bacteria-derived vesicle as an active ingredient. The present inventors have confirmed that, when a Lactobacillus sp. bacteria-derived vesicle is administered to a stress and depression animal model, resistance to stress efficiently increases, and an effect of treating chronically persisting long-term depression behavior is exhibited, and thus the Lactobacillus sp. bacteria-derived vesicle, according to the present invention, is expected to be capable of being usefully employed in developing a medicine or a functional health food, etc., for preventing, reducing the symptoms of or treating a mental disorder such as stress, anxiety disorder, post-traumatic stress disorder, panic disorder, depression, autism spectrum disorder, attention deficit hyperactivity disorder and schizophrenia.

The invention claimed is: 
     
       1. A method for preventing or treating a mental disorder, comprising:
 administering an inhalant composition consisting of  Lactobacillus  sp. bacteria-derived vesicles as an active ingredient and a pharmaceutically acceptable carrier or inhalant ingredients to a subject in need thereof; 
 wherein the vesicles are isolated from a culture solution of  Lactobacillus  sp. bacteria, food produced by adding  Lactobacillus  sp. bacteria, or a combination thereof, 
 wherein the vesicles are derived from  Lactobacillus plantarum, Lactobacillus casei , or a combination thereof; and 
 wherein the mental disorder is a disease selected from the group consisting of stress, anxiety disorders, post-traumatic stress disorder (PTSD), panic disorder, autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), and schizophrenia. 
 
     
     
       2. The method of  claim 1 , wherein the vesicles have an average diameter of 10 to 1,000 nm. 
     
     
       3. The method of  claim 1 , wherein the vesicles were naturally or artificially released from  Lactobacillus  sp. bacteria. 
     
     
       4. A method for improving a mental disorder, comprising:
 administering an inhalant composition consisting of  Lactobacillus  sp. bacteria-derived vesicles as an active ingredient and a pharmaceutically acceptable carrier or inhalant ingredients to a subject in need thereof; 
 wherein the vesicles are isolated from a culture solution of  Lactobacillus  sp. bacteria, food produced by adding  Lactobacillus  sp. bacteria, or a combination thereof, 
 wherein the vesicles are derived from  Lactobacillus plantarum, Lactobacillus casei , or any combination thereof; and 
 wherein the mental disorder is a disease selected from the group consisting of stress, anxiety disorders, post-traumatic stress disorder (PTSD), panic disorder, autism spectrum disorders, attention deficit hyperactivity disorder (ADHD), and schizophrenia. 
 
     
     
       5. The method of  claim 4 , wherein the vesicles have an average diameter of 10 to 1,000 nm. 
     
     
       6. The method of  claim 4 , wherein the vesicles were naturally or artificially released from  Lactobacillus  sp. bacteria.