Tuning a broad acting antimicrobial textile to act as a narrow spectrum antimicrobial textile

Abstract

The disclosed subject matter relates to a textile or fabric and methods of making them that includes a composition that selectively binds odor causing and/or pathogenic bacteria, but avoids binding beneficial bacteria and an antimicrobial composition that kills the selectively bound odor causing and/or pathogenic bacteria. The composition that selectively binds odor causing and/or pathogenic bacteria can be a peptide.

The invention claimed is: 
     
       1. A method of treating a fabric to selectively kill bacteria, comprising: binding an antimicrobial composition and a peptide to the fabric, wherein the peptide is selected from the group consisting of: 
       
         
           
                 
               
                   (SEQ ID NO: 7) 
                 
                   GGSGGSYSTCDFIM; 
                 
                     
                 
                   (SEQ ID NO: 8) 
                 
                   GGSGGSKKHRKHRKHRKH; 
                 
                     
                 
                   (SEQ ID NO: 1) 
                 
                   GGSGGNGVVLTL; 
                 
                     
                 
                   (SEQ ID NO: 2) 
                 
                   GGSGGTWTKKLK; 
                 
                     
                 
                   (SEQ ID NO: 3) 
                 
                   GGSGGNRVVWQGVVP; 
                 
                     
                 
                 
                 
               
                   (SEQ ID NO: 4) 
                     
                 
                   GGSGGSWQHVFT; 
                     
                 
                     
                 
                   (SEQ ID NO: 5) 
                     
                 
                   GGSGGGVVWNSWGKCV; 
                     
                 
                     
                 
                   (SEQ ID NO: 6) 
                     
                 
                   GGSGGIGGVSGGLTG; 
                     
                 
                   and 
                     
                 
                     
                 
                   (SEQ ID NO: 9) 
                     
                 
                   GGSGGSYSTCYFIM;  
                     
                 
                   and 
                     
                 
             
                
                
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
             
                
                
                
                
                
                
                
                
                
                
                
                
                
               
            
           
         
         wherein the binding step includes binding the antimicrobial composition before binding the peptide. 
       
     
     
       2. The method of  claim 1 , wherein the antimicrobial composition is polyhexamethylene biguanidine (PHMB). 
     
     
       3. The method of  claim 1 , wherein the fabric includes an antimicrobial surface and the antimicrobial composition and the peptide are bound to the antimicrobial surface. 
     
     
       4. The method of  claim 1 , wherein binding the antimicrobial includes using a dip press-coating protocol or an EDC coupling reaction. 
     
     
       5. The method of  claim 1 , wherein binding the peptide includes using an EDC coupling reaction. 
     
     
       6. The method of  claim 1 , wherein the peptide binds to and the antimicrobial composition kills odor causing or pathogenic bacteria. 
     
     
       7. The method of  claim 1 , wherein the peptide selectively binds to at least one bacteria of  Staphylococcus aureus, Pseudomonas aeruginosa, Corynebacterium  and  Micrococcus luteus  and the antimicrobial composition kills at least one bacteria.