Materials for preparing intraocular lens

Abstract

The present invention relates to a material for preparing an intraocular lens. In particular, it relates to an ophthalmic medical material suitable for manufacture of micro-incision intraocular lens, having suitable water content and a suitable refractive index.

The invention claimed is: 
     
       1. A material comprising a copolymer comprising hydrophilic acrylates monomers and hydrophobic acrylates monomers, wherein the molar ratio of the hydrophilic acrylates monomers to the hydrophobic acrylates monomers is from 42.5:57.5 to 45:55, wherein the hydrophilic acrylates monomers are selected from the group consisting of hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl methacrylate, hydroxypropyl acrylate, vinyl pyrrolidone, ethoxyethoxyethyl methacrylate, ethoxyethoxyethyl acrylate, ethoxyethyl methacrylate, ethoxyethyl acrylate, methoxyethyl methacrylate, methoxyethyl acrylate, 1,3-butylene glycol dimethacrylate, ethylene glycol dimethacrylate, polyethylene glycol methacrylate, polyethylene glycol 200 dimethacrylate, polyethylene glycol acrylate, poly(ethylene glycol) methyl ether methacrylate, polyethylene glycol methyl ether acrylate, glycidyl methacrylate, glycidyl acrylate, acrylic acid, methacrylic acid, 2-(trifluoromethyl) acrylic acid, phenyl acrylic acid, acrylamide, methacrylamide, N-methylol acrylamide, N-methylol methacrylamide, and a mixture thereof,
 wherein the hydrophobic acrylates monomers are selected from the group consisting of methyl methacrylate, ethyl methacrylate, ethyl acrylate, butyl methacrylate, butyl acrylate, hexyl methacrylate, hexyl acrylate, isopropyl methacrylate, isopropyl acrylate, isobutyl methacrylate, isobutyl acrylate, tert-butyl methacrylate, tert-butyl acrylate, isooctyl methacrylate, isooctyl acrylate, isodecyl acrylate, isodecyl methacrylate, lauryl methacrylate, lauryl acrylate, octadecyl methacrylate, octadecyl acrylate, 9-anthryl methyl methacrylate, 9-anthryl methyl acrylate, cyclohexyl methacrylate, cyclohexyl acrylate, dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate, N,N-dimethylmethacrylamide, N,N-dimethylacrylamide, N,N-diethylaminoethyl acrylate, N,N-diethylaminoethyl methacrylate, N-tert-butyl acrylamide, N-tert-butyl methacrylamide, N-isopropyl acrylamide, N-isopropyl methacrylamide, tetrahydrofurfuryl methacrylate, tetrahydrofurfuryl acrylate, trifluoroethyl methacrylate, trifluoroethyl acrylate, hexafluorobutyl methacrylate, hexafluorobutyl acrylate, 2-perfluorodecylethyl acrylate, 2-perfluorodecylethyl methacrylate, 2-(perfluorooctyl)ethyl methacrylate, 2-(perfluorooctyl)ethyl acrylate, acetone glycidyl methacrylate, acetone glycidyl acrylate, tetrahydrofuryl acrylate, tetrahydrofurfuryl methacrylate, phenyl methacrylate, phenyl acrylate, phenylethyl methacrylate, phenylethyl acrylate, phenoxyethyl methacrylate, phenoxyethyl acrylate, benzyl methacrylate, benzyl acrylate, acetoacetoxyethyl methacrylate, acetoacetoxyethyl acrylate, diacetone acrylamide, diacetone methacrylamide, allyl methacrylate, phenoxyethyl acrylate, and a mixture thereof, and wherein the material has the following properties: 
 (a) a water content at 35° C. that is 5 to 8 wt %; 
 (b) a refractive index when the material is hydrated at 35° C. that is 1.49 to 1.54; and 
 (c) a glass transition temperature of 20 to 35° C., wherein the material is in a dry state, 
 in which the refractive index of the material after water saturation satisfies this formula:
     n=v   w   n   w +(1− v   w ) n   p  
 
 
 wherein v w  is the water content, n w  is the refractive index of water, and n p  is the refractive index of the dry acrylate polymer. 
 
     
     
       2. The material according to  claim 1  having a glass transition temperature of 20 to 30° C., wherein the material is in a dry state. 
     
     
       3. The material according to  claim 1  having an elongation at break in a wet state that is more than 180% and a breaking strength when hydrated that is more than 2.5 MPa. 
     
     
       4. The material according to  claim 1 , further comprising at least one fluorescent agent and/or at least one photosensitizer;
 wherein the at least one fluorescent agent and/or the at least one photosentitizer participate in the polymerization when forming the copolymer material; or 
 the at least one fluorescent agent and/or the at least one photosentitizer are added to the copolymer material by physical dispersion when forming the copolymer material; or 
 the at least one fluorescent agent and/or the at least one photosentitizer are fixed on the surface of the copolymer material by surface grafting or surface modification; or 
 the at least one fluorescent agent and/or the at least one photosentitizer are fixed on the surface of the copolymer material by surface-coating. 
 
     
     
       5. The material according to  claim 4  wherein the fluorescent agent is selected from the group consisting of fluorescein, cyanine fluorescent dyes, fluorescein isothiocyanate, fluorescent rhodamine substances, fluorescent lanthanide chelates, P-phycoerythrin (PE), substances that produce fluorescence upon enzyme action, Polypida chlorophyllin (PerCP), propidium iodide, a mixture of any of the above substances, and a nanomaterial having any of the above substances. 
     
     
       6. The material according to  claim 4 , wherein the photosensitizer is selected from the group consisting of indole monocyanine, indole carbocyanine, indole dicarbocyanine, indole tricarbocyanine, tricarbocyanine dyes, benzoindole semicyanine dyes, indole squarylium dyes, chlorophyll, pheophytin, pheophorbide a, dihydroporphine e6, purpurin 18, dihydroporphine p6, dihydroporphine f, protoporphyrin, hematoporphyrin (HpD), porfimer sodium, photocarcinorin (PSD-007), nanogold, nanotungsten oxides, nano-copper sulfides, nano-iron oxides, nano-nickel carbide, nano-molybdenum oxide, fluorescein O-acrylate and fluorescein O-methacrylate, other water-soluble or fat-soluble based on the modification of the above photosensitizers, and a mixture thereof. 
     
     
       7. A medical device or equipment made of the material according to  claim 1 , wherein the device or equipment is selected from the group consisting of an intraocular lens, a corneal contact lens, an orthokeratology lens, an iris hook, an artificial lens, an artificial cornea, a corneal inner ring, a capsular bag tension ring, an intracorneal lens, a glaucoma drainage valve, a drug sustained-release carrier, an intraocular filler, a fundus filler, glasses, goggles, a medical equipment lens, a medical treatment device and a medical detection device with fluorescent properties. 
     
     
       8. The material according to  claim 1 , wherein the water content at 35° C. is from 6 to 8 wt. %. 
     
     
       9. The material according to  claim 1 , wherein, the water content at 35° C. is from 7 to 8 wt. %. 
     
     
       10. The material according to  claim 1 , wherein, the refractive index at 35° C. is from 1.49 to 1.53. 
     
     
       11. The material according to  claim 1 , wherein, the refractive index at 35° C. is from 1.50 to 1.52. 
     
     
       12. The material according to  claim 1 , wherein the hydrophilic acrylates monomers are hydroxyethyl methacrylate. 
     
     
       13. The material according to  claim 1 , wherein the hydrophobic acrylates monomers are ethyl acrylate or phenoxyethyl acrylate. 
     
     
       14. The material according to  claim 2 , wherein the glass transition temperature is from 20 to 25° C.