Antiviral compounds and methods

Abstract

The invention relates to compounds having antiviral and methods utilizing the compounds to treat viral infections.

The invention claimed is: 
     
       1. A pharmaceutical composition comprising a compound selected from the group consisting of:
 4-phenylbenzoylguanidine 
 
       
         
           
           
               
               
           
         
         N-(3-phenylpropanoyl)-N′-phenyl-guanidine 
       
       
         
           
           
               
               
           
         
         N,N′-bis(3-phenylpropanoyl)guanidine 
       
       
         
           
           
               
               
           
         
         N-(6-Hydroxy-2-naphthoyl)-N′-phenyl-guanidine 
       
       
         
           
           
               
               
           
         
         N-Benzoyl-N′-cinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         (5-Phenyl-penta-2,4-dienoyl)guanidine 
       
       
         
           
           
               
               
           
         
         4-phenylcinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         5-(3′-bromophenyl)penta-2,4-dienoylguanidine 
       
       
         
           
           
               
               
           
         
         3-phenylcinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         5-(2′-bromophenyl)penta-2,4-dienoylguanidine 
       
       
         
           
           
               
               
           
         
         2-cyclohexylcinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         2-phenylcinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         2-(cyclohex-1-en-1yl)cinnamoylguanidine 
       
       
         
           
           
               
               
           
         
         and a pharmaceutically acceptable salt, 
         wherein the composition has anti-viral activity. 
       
     
     
       2. The compound according to  claim 1  wherein the compound is selected from:
 2-phenylcinnamoylguanidine, 
 3-phenylcinnamoylguanidine, 
 4-phenyl cinnamoylguanidine, 
 5-(2′-bromophenyl)penta-2,4-dienoylguanidine, 
 5-(3′-bromophenyl)penta-2,4-dienoylguanidine, 
 N-(6-Hydroxy-2-naphthoyl)-N′-phenylguanidine, and 
 N,N′-Bis(3-phenylpropanoyl)guanidine, 
 or a pharmaceutically acceptable salt thereof. 
 
     
     
       3. A method for the therapeutic or prophylactic treatment of a subject infected with or exposed to a virus, comprising administering to the subject a compound according to  claim 1 , wherein said virus is a Lentivirus, Human Immunodeficiency Virus (HIV), a Coronavirus, the Hepatitis C virus or Equine Arteritis virus. 
     
     
       4. The pharmaceutical composition according to  claim 1  wherein the compound is selected from:
 N-(6-Hydroxy-2-naphthoyl)-N′-phenyl-guanidine, 
 5-(3′-bromophenyl)penta-2,4-dienoylguanidine, 
 5-(2′-bromophenyl)penta-2,4-dienoylguanidine and 
 2-phenylcinnamoylguanidine. 
 
     
     
       5. The pharmaceutical composition according to  claim 1 , wherein the composition has activity against Lentivirus, Human Immunodeficiency Virus (HIV), a Coronavirus, Hepatitis C virus or Equine Arteritis virus.