US11123423B2ActiveUtilityA1

Zika virus vaccine

44
Assignee: HARVARD COLLEGEPriority: Oct 19, 2016Filed: Oct 19, 2017Granted: Sep 21, 2021
Est. expiryOct 19, 2036(~10.2 yrs left)· nominal 20-yr term from priority
Inventors:Sean WhelanSayantan BoseJoseph Timpona
C12N 2770/24171Y02A50/30A61K 2039/5258A61K 2039/5256C12N 2760/20243C12N 2770/24121C12N 2770/24134C12N 2760/20234C12N 7/00C12N 2760/20241A61K 39/205A61K 39/12C12N 2760/20223C12N 2760/20021
44
PatentIndex Score
0
Cited by
16
References
6
Claims

Abstract

Compositions and methods useful for treating and/or preventing a Zika virus infection are provided.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the nucleic acid encoding the Zika virus E protein has a sequence that is at least 90% identical to SEQ ID NO:2. 
     
     
       2. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, further comprising in its genome a nucleic acid sequence encoding a Zika virus precursor membrane (prM) protein or fragment thereof, wherein the nucleic acid encoding Zika virus prM has a sequence that is at least 90% identical to SEQ ID NO: 3. 
     
     
       3. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, further comprising in its genome a nucleic acid sequence encoding a Zika virus precursor membrane (prM) protein or fragment thereof and a nucleic acid sequence encoding Zika virus capsid (C) protein or fragment thereof, wherein the nucleic acid encoding Zika virus capsid (C) protein has a sequence that is at least 90% identical to SEQ ID NO:4. 
     
     
       4. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:5. 
     
     
       5. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:6. 
     
     
       6. A recombinant vesicular stomatitis virus (VSV) comprising in its genome a nucleic acid sequence encoding a Zika virus envelope (E) protein or fragment thereof, wherein the genome of the recombinant VSV has a nucleic acid sequence that is at least 90% identical to SEQ ID NO:7.

Join the waitlist — get patent alerts

Track US11123423B2 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.