Nasal implant assembly

Abstract

Provided is a nasal implant assembly comprising a hollow implant having a distal end and a proximal end, the distal end configured to have a segment deposited with magnetic particles; and a medical syringe configured to be attachable to the proximal end of the hollow implant and also configured to be capable of retaining and transporting a magnetically active fluid composition through the implant to a nasal cavity of a subject. Also provided is a method of treating chronic rhinosinusitis in a subject, the method comprising the steps of positioning a nasal implant having magnetic particles into a nasal cavity; loading a medical syringe with a magnetically active fluid composition; and transporting the loaded magnetically active fluid composition to the nasal cavity to treat chronic rhinosinusitis.

What is claimed: 
     
       1. An indwelling device configured for implantation in a nasal sinus cavity, the device comprising:
 a hollow polymeric catheter having a distal portion and a proximal portion, the catheter including pores only in the distal portion, the distal portion including a sponge material that releases an infused fluid drug substance at the distal portion over time and into the nasal sinus cavity to treat chronic rhinosinusitis (CRS), and a proximal end of the proximal portion attachable to a medical syringe, the fluid drug substance infused with magnetic particles; and 
 a magnetic particle coating around the pores targeting and concentrating the drug substance at and around the nasal sinus cavity by magnetic attractions to the magnetic particles of the infused fluid drug substance to treat the CRS. 
 
     
     
       2. The implantable device of  claim 1 , wherein the magnetic particle coating is external to the catheter. 
     
     
       3. The implantable device of  claim 1 , wherein only a portion of the pores are coated with the magnetic particle coating. 
     
     
       4. The implantable device of  claim 1 , wherein the distal portion includes a curled or pigtail shape. 
     
     
       5. The implantable device of  claim 1 , wherein the distal portion includes an open or closed end. 
     
     
       6. An at least partially implantable medical assembly configured for implantation in a sinus cavity, the assembly comprising:
 an indwelling implant having a hollow polymeric catheter having a distal portion and a proximal portion, the catheter including pores only in the distal portion, a sponge material in the distal portion that absorbs a liquid drug substance and releases the drug substance over time in the distal portion to treat chronic rhinosinusitis (CRS), and first magnetic particles coated around the pores, the liquid drug substance infused with second magnetic particles, the first magnetic particles configured to target and concentrate the liquid drug substance at and around the nasal sinus cavity by magnetic attractions to the second magnetic particles to treat the CRS; and 
 a medical syringe configured to be attachable to a proximal end of the proximal portion of the catheter and to provide the liquid drug substance. 
 
     
     
       7. The medical assembly of  claim 6 , wherein the assembly further comprises a connector configured to connect the implant and the medical syringe. 
     
     
       8. The medical assembly of  claim 6 , wherein the medical syringe is configured to have a fixed elongated tip. 
     
     
       9. A method of treating chronic rhinosinusitis (CRS) of a patient, comprising:
 providing an indwelling implantable device including a hollow polymeric catheter having a distal portion and a proximal portion, the catheter including pores only in the distal portion, a sponge material in the distal portion that absorbs a liquid drug substance and releases the drug substance over time in the distal portion to treat CRS and a magnetic particle coating around the pores; 
 providing a medical syringe configured to retain a magnetically active fluid composition containing a drug substance; and 
 transporting the magnetically active fluid composition to a nasal cavity of the patient to target and concentrate the drug substance at or around a nasal sinus cavity of the patient by magnetic attractions between the magnetically active fluid composition and the magnetic particle coating to treat the CRS. 
 
     
     
       10. The method of  claim 9 , wherein the drug substance includes an anti-inflammatory agent. 
     
     
       11. The method of  claim 9 , wherein the drug substance includes mometasone furoate. 
     
     
       12. The method of  claim 9 , further comprising adjusting a shape of the implantable device by:
 traversing an insert into the implantable device to adjust the shape of the implantable device; 
 applying heat to the implantable device to adjust the shape of the implantable device; 
 applying cold to the implantable device to adjust the shape of the implantable device; or applying light, to the implantable device to adjust the shape of the implantable device. 
 
     
     
       13. The method of  claim 9  further comprising before implanting the implantable device, pre-loading the implantable device with a second drug substance. 
     
     
       14. The method of  claim 13 , wherein the second drug substance is different from the drug substance. 
     
     
       15. The method of  claim 13 , wherein pre-loading the implantable device includes pre-loading only the distal end of the implantable device with the drug substance. 
     
     
       16. The method of  claim 9 , wherein the magnetic particle coating is non-biocompatible and the magnetic particle coating is coated with a biocompatible coating. 
     
     
       17. The method of  claim 9  further comprising inserting the medical syringe into the implantable device to the distal end of the implantable device. 
     
     
       18. The method of  claim 9  further comprising forcing, by a closed distal end of the implantable device, the magnetically active fluid composition through the pores.