Topical compositions comprising polyolprepolymers, stem cell, and cannabinoids for skin care

Abstract

The present invention relates to compositions and methods for the prevention and treatment of skin disorders. In particular, the application describes topical compositions and methods of treatments comprising the combined use of one or more cannabinoids, or use of an ingredient that works on the endocannabinoid system, such as but not limited to, Palmitoylethanolamide (PEA), polyolprepolymers and stem cell extract.

The invention claimed is: 
     
       1. A topical emulsion consisting essentially of an isolated cannabinoid selected from the group consisting of cannabigerolic acid, cannabigerolic acid monomethylether, cannabigerol, cannabigerol monomethylether, cannabigerovarinic acid, cannabigerovarin, cannabichromenic acid, cannabichromene, cannabichromevarinic acid, cannabichromevarin, cannabidiolic acid, cannabidiol, cannabidiol monomethylether, cannabidiol-C4, cannabidivarinic acid, cannabidivarin, cannabidiorcol and mixtures thereof; a stem cell extract; and a polyolprepolymer. 
     
     
       2. The topical emulsion of  claim 1 , wherein the cannabinoid is present in a concentration between 0.1 and 30% by weight of the topical emulsion; and wherein the polyolprepolymer is present in a concentration between 0.1 and 10% by weight of the topical emulsion. 
     
     
       3. The topical emulsion of  claim 1 , wherein the polyolprepolymer is polyolprepolymer-2, -14, or -15, or a combination thereof. 
     
     
       4. The topical emulsion of  claim 1 , further consisting essentially of tetrahexylecyl ascorbate. 
     
     
       5. The topical emulsion of  claim 1 , further consisting essentially of a component selected from the group consisting of an alpha hydroxy acid, a lactic acid, citric acid, glycolic acid, mandelic acid, benzylic acid, malic acid, tartaric acid, gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharic acid lactone, pantoyllactone, glucoheptonolactone, mannonolactone, galactoheptonolactone and mixtures thereof. 
     
     
       6. The topical emulsion of  claim 1 , further consisting essentially of a benzoyl peroxide. 
     
     
       7. The topical emulsion of  claim 1 , further consisting essentially of a hydroxy acid. 
     
     
       8. The topical emulsion of  claim 1 , further consisting essentially of a stabilizer selected from the group consisting of guar gum, xanthan gum, cellulose, hyaluronic acid, polyvinyl pyrrolidone, alginate, chondritin sulfate, poly gamma glutamic acid, gelatin, chitosin, corn starch, flour and mixtures thereof, in an amount from about 0.25% to about 30% (w/v). 
     
     
       9. The topical emulsion of  claim 1 , further consisting essentially of hemp oil. 
     
     
       10. The topical emulsion of  claim 1 , further consisting essentially of one or more of a thickening agent, an antibiotic, an antiseptic agent, an antifungal, an analgesic, an antiviral agent or a UV absorbing agent in an amount between 0.1 and 5% by weight of the composition;
 wherein the thickening agent is selected from the group consisting of xanthan gum, carrageen, an alginate and cellulose gum; 
 wherein the antibiotic is selected from the group consisting of ampicillin, bacampicillin, carbenicillin indanyl, mezlocillin, piperacillin, ticarcillin, amoxicillin-clavulanic acid, ampicillin-sulbactam, benzylpenicillin, cloxacillin, dicloxacillin, methicillin, oxacillin, penicillin G, penicillin V, piperacillin tazobactam, ticarcillin clavulanic acid, nafcillin, procaine penicillin, cefadroxil, cefazolin, cephalexin, cephalothin, cephapirin, cephradine, cefaclor, cefamandol, cefonicid, cefotetan, cefoxitin, cefprozil, ceftmetazole, cefuroxime, loracarbef cefdinir, ceftibuten, cefoperazone, cefixime, cefotaxime, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, cefepime, azithromycin, clarithromycin, clindamycin, dirithromycin, erythromycin, lincomycin, troleandomycin, cinoxacin, ciprofloxacin, enoxacin, gatifloxacin, grepafloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, sparfloxacin, trovafloxacin, oxolinic acid, gemifloxacin, perfloxacin, imipenem-cilastatin, meropenem, aztreonam, and mixtures thereof; 
 wherein the antiseptic agent is selected from the group consisting of iodine, manuka honey, octenidine dihydrochloride, phenol, polyhexanide, sodium chloride, sodium hypochlorite, calcium hypochlorite, sodium bicarbonate, methyl paraben, benzoyl peroxide, sodium dehydroacetate, and mixtures thereof; 
 wherein the antifungal is selected from the group consisting of amphotericin B, candicidin, filipin, hamycin, natamycin, nystatin, rimocidin, bifonazole, butoconazole, clotrimazole, econazole, fenticonazole, isoconazole, ketoconazole, luliconazole, miconazole, omoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, albaconazole, fluconazole, isavuconazole, itraconazole, posaconazole, ravuconazole, terconazole, voriconazole, abafungin, amorolfin, butenafine, naftifine, terbinafine, anidulafungin, caspofungin, micafungin, benzoic acid, ciclopirox, flucytosine, griseofulvin, haloprogin, tolnaftate, undecylenic acid, crystal violet, balsam, and mixtures thereof; 
 wherein the analgesic is selected from the group consisting of methyl salicylate, codeine, morphine, methadone, pethidine, buprenorphine, hydromorphine, levorphanol, oxycodone, fentanyl, and mixtures thereof; 
 wherein the antiviral agent is selected from the group consisting of acyclovir, famciclovir, penciclovir, valacyclovir, trifluridine, docosanol, amantadine, rimantadine, oseltamivir, zanamivir, and mixtures thereof; and 
 wherein the UV absorbing or barrier agent is selected from the group consisting of benzone compounds, glyceryl PABA, roxadimate, octocrylene, octyl methoxycinnamate, ethoxyethyl p-methoxycinnamate, homomenthyl salicylate, ethylhexyl salicylate, trolamine salicylate, ecamsule, ensulizole, bemotrizinol, bisoctrizole, zinc oxide, titanium dioxide, and mixtures thereof. 
 
     
     
       11. A method to treat a skin disorder or rejuvenate the skin in a human in need thereof consisting essentially of topically administering to the human the topical emulsion of  claim 1 . 
     
     
       12. The method of  claim 11 , wherein the skin disorder is selected from the group consisting of eczema, psoriasis, dermatitis, itching dermatosis, rosacea, perioral dermatitis, acne, and melanoma. 
     
     
       13. The method of  claim 11 , wherein the condition of the human's skin is selected from the group consisting of pruritus, dryness, skin rash, redness, swelling of the skin, itching, crusting, flaking, blistering, cracking, oozing, and bleeding. 
     
     
       14. The method of  claim 12 , wherein the dermatitis is selected from the group consisting of atopic dermatitis, contact dermatitis, xerotic eczema, and seborrheic dermatitis. 
     
     
       15. The method of  claim 11 , wherein the topical emulsion is administered to the human in an amount between about 100 nmol to about 1 micro mol/cm2.