Vitamin supplement compositions with enhanced bioavailability

Abstract

A vitamin supplement composition that includes a complex with enhanced bioavailability having a vitamin B complex, wherein the vitamin B complex includes: (a) a first vitamin, wherein the first vitamin comprises a form of vitamin B 6 ; (b) a second vitamin, wherein the second vitamin comprises a form of vitamin B 9 ; (c) a third vitamin, wherein the third vitamin comprises a form of vitamin B 12 ; and (d) wherein the first vitamin, the second vitamin, and the third vitamin cooperate synergistically to enhance bioavailability of the same. The present invention further includes a method of administering a vitamin supplement composition to an individual having, for example, MTHFR deficiency.

What is claimed and desired to be secured by Letters Patent of the United States is: 
     
       1. A vitamin supplement composition that comprises a complex with enhanced bioavailability, comprising:
 a vitamin B complex, wherein the vitamin B complex comprises:
 a first vitamin, wherein the first vitamin comprises a form of vitamin B 6 ; 
 a second vitamin, wherein the second vitamin comprises the structure of formula IV or nutraceutically acceptable salts or solvates thereof: 
 
 
       
         
           
           
               
               
           
         
         and
 a third vitamin, wherein the third vitamin comprises a form of vitamin B 12 . 
 
       
     
     
       2. The vitamin supplement composition according to  claim 1 , wherein the first vitamin comprises the structure of formula I or nutraceutically acceptable salts or solvates thereof: 
       
         
           
           
               
               
           
         
         wherein R 1 -R 6 , are each independently selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); 
         wherein at least three of R 1 -R 5  comprise OH; and 
         wherein X 1 -X 3  are each independently selected from the group consisting of N—R 6 ; O; and S. 
       
     
     
       3. The vitamin supplement composition according to  claim 1 , wherein the first vitamin comprises the structure of formula II or nutraceutically acceptable salts or solvates thereof: 
       
         
           
           
               
               
           
         
       
     
     
       4. The vitamin supplement composition according to  claim 1 , wherein the second vitamin comprises the structure of formula III or nutraceutically acceptable salts or solvates thereof: 
       
         
           
           
               
               
           
         
         wherein R 1 -R 12 , are each independently selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s); and 
         wherein X 1 -X 4  are each independently selected from the group consisting of N—R 12 ; O; and S. 
       
     
     
       5. The vitamin supplement composition according to  claim 1 , wherein the third vitamin comprises the structure of formula V or nutraceutically acceptable salts or solvates thereof: 
       
         
           
           
               
               
           
         
         wherein R 1  is selected from the group consisting of H; OH; and an alkyl, cycloalkyl, polycycloalkyl, heterocycloalkyl, aryl, alkaryl, aralkyl, alkoxy, alkanoyl, aroyl, alkenyl, alkyl-alkenyl, alcohol, ether, ketone, carboxylic acid, acid halide, acid anhydride, ester, and/or amide group containing approximately 1 to approximately 25 carbon atom(s). 
       
     
     
       6. The vitamin supplement composition according to  claim 1 , wherein the third vitamin comprises the structure of formula VI or nutraceutically acceptable salts or solvates thereof: 
       
         
           
           
               
               
           
         
       
     
     
       7. The vitamin supplement composition according to  claim 1 , wherein the weight ratio of the first vitamin to the second vitamin to the third vitamin ranges from approximately 300:50:1 to approximately 30:50:1 by weight of the total vitamin B complex. 
     
     
       8. The vitamin supplement composition according to  claim 1 , wherein the weight ratio of the first vitamin to the second vitamin to the third vitamin is approximately 200:55:1 by weight of the total vitamin B complex. 
     
     
       9. The vitamin supplement composition according to  claim 1 , further comprising at least one of vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, thiamin, riboflavin, niacin, biotin, pantothenic acid, calcium, iron, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, choline, boron, lutein, lycopene, inositol, fruit and/or vegetable blend, and combinations thereof. 
     
     
       10. The vitamin supplement composition according to  claim 1 , further comprising at least one of sweeteners, beeswax, carnuba wax, flavors, emulsifiers, preservatives, colors, glaze, syrups, silica, malic acid, citric acid, magnesium stearate, cellulose, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, maltodextrin, sunflower lecithin, guar gum, sunflower oil, coconut oil, vegetable cellulose, stearic acid, vegetable magnesium stearate, pectin, sodium citrate, dicalcium phosphate, and combinations thereof. 
     
     
       11. The vitamin supplement composition according to  claim 1 , further comprising a vitamin/mineral selected from the group consisting of vitamin A, thiamin, riboflavin, niacin, pantothenic acid, biotin, vitamin C, choline, vitamin D, vitamin E, vitamin K, calcium, chloride, chromium, copper, fluoride, iodine, iron, magnesium, manganese, molybdenum, nickel, phosphorus, potassium, silicon, selenium, sodium, sulfur, tin, vanadium, zinc, and combinations thereof. 
     
     
       12. The vitamin supplement composition according to  claim 1 , further comprising an amino acid selected from the group consisting of L-alanine, L-arginine, L-asparagine, L-aspartic acid, L-cysteine, L-glutamine, L-glutamic acid, L-glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, and combinations thereof. 
     
     
       13. A vitamin supplement composition having a vitamin complex with enhanced bioavailability, comprising:
 a vitamin B complex, wherein the vitamin B complex comprises:
 a first vitamin, wherein the first vitamin comprises [(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid; 
 a second vitamin, wherein the second vitamin comprises the structure of formula IV or nutraceutically acceptable salts or solvates thereof: 
 
 
       
         
           
           
               
               
           
         
         and
 a third vitamin, wherein the third vitamin comprises methylcobalamin. 
 
       
     
     
       14. A method for treating an individual, comprising the steps of:
 orally administering a vitamin B complex, wherein the vitamin B complex comprises:
 a first vitamin, wherein the first vitamin comprises a form of vitamin B 6 ; 
 a second vitamin, wherein the second vitamin comprises the structure of formula IV or nutraceutically acceptable salts or solvates thereof: 
 
 
       
         
           
           
               
               
           
         
         
           a third vitamin, wherein the third vitamin comprises a form of vitamin B 12 ; and 
         
         wherein at least two of the first vitamin, the second vitamin, and the third vitamin cooperate synergistically to enhance bioavailability of the same.