US10610558B2ActiveUtilityA1

Prophylactic and/or therapeutic agent for NAFLD/NASH

57
Assignee: ADABIO CO LTDPriority: Nov 27, 2015Filed: Nov 25, 2016Granted: Apr 7, 2020
Est. expiryNov 27, 2035(~9.4 yrs left)· nominal 20-yr term from priority
Inventors:Katsuya HiraishiFumie JimmaHiroyuki SomaTaro AdachiMasakazu AdachiIppei YamaokaTomohiro Kagawa
A23L 33/105A23V 2002/00A23L 2/385A61K 36/736A61P 1/16A23V 2200/30
57
PatentIndex Score
0
Cited by
17
References
9
Claims

Abstract

The present invention provides a prophylactic and/or therapeutic agent for non-alcoholic fatty liver disease (NAFLD), and particularly non-alcoholic steatohepatitis (NASH) comprising an ume (Japanese apricot) juice concentrate or a processed product thereof. The prophylactic and/or therapeutic agent is obtained by utilizing a component contained in a plant or a processed product thereof, and hence is safe and easily taken. It has been confirmed that when the ume juice concentrate or the processed product thereof is orally administered to a streptozocin (STZ)-induced NAFLD model mouse or an STZ-induced NASH model mouse, liver fibrogenesis can be reduced.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method for treating or lowering the incidence or progression of non-alcohol steatohepatitis (NASH), comprising administering an effective amount of an ume juice concentrate or a processed product thereof to a subject in need of reduction of fibrogenesis in liver tissue. 
     
     
       2. The method according to  claim 1 , wherein the processed product of the concentrate is a neutralized processed product of the concentrate. 
     
     
       3. The method according to  claim 1 , wherein the concentrate is a heated concentrate. 
     
     
       4. The method according to  claim 1 , wherein the ume juice concentrate or the processed product thereof is administered orally. 
     
     
       5. The method according to  claim 1 , wherein the ume juice concentrate or the processed product thereof is used as a dietary supplement. 
     
     
       6. The method according to  claim 2 , wherein the concentrate is a heated concentrate. 
     
     
       7. The method according to  claim 2 , wherein the ume juice concentrate or the processed product thereof is administered orally. 
     
     
       8. The method according to  claim 3 , wherein the ume juice concentrate or the processed product thereof is administered orally. 
     
     
       9. The method according to  claim 6 , wherein the ume juice concentrate or the processed product thereof is administered orally.

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