Proton induced boron capture therapy

Abstract

The present disclosure provides methods of treating a biological tissue using a proton beam. A method includes the steps of: irradiating a proton beam to a biological tissue containing a reactant. The reactant includes a composite. The composite reacts with at least one proton from the proton beam and releases at least one α particle or γ rays. The α particle or γ rays reacts with the biological tissue. Another method includes the steps of: providing a reactant, the reactant comprising a composite; introducing the reactant into a biological tissue, the reactant being distributed in the biological tissue; and irradiating the biological tissue with the proton beam. The composite reacts with at least one proton from the proton beam to release at least one α particle or γ rays, and the α particle or the γ rays reacts with the biological tissue.

What is claimed is: 
     
       1. A method of treating a biological tissue using a proton beam, comprising steps of:
 introducing a reactant into a biological tissue, the reactant comprising a composite and being distributed in the biological tissue; and 
 irradiating the biological tissue with the proton beam, 
 wherein the composite comprises  10 B and  11 B, the composite reacts with at least one proton from the proton beam to release at least one α particle or γ rays, and the α particle or the γ rays reacts with the biological tissue. 
 
     
     
       2. The method of treating a biological tissue using a proton beam according to  claim 1 , wherein the composite is, selected from a group consisting of (L)-4-dihydroxy-borylphenylalanine (BPA), sodium mercaptoun decahydro-closo-dodecaborate (BSH), carbohydrate derivatives of BSH, sodium salt of closo-B 10 H 10   2−  (GB-10), β-5-o-carboranyl-2V-deoxyuridine (D-CDU), 3-(dihydroxypropyl-carboranyl-pentyl) thymidine derivative (N5-20H), boron-containing porphyrins (H 2 DCP), dequalinium derivatives (DEQ-B), derivatives of trimethoxyindoles, aziridines, derivatives of acridines, phenanthridines, carboranyl polyamines, Pt(II)-amine complexes, dibenzimidazoles, tribenzimidazoles, glucose molecules mannose molecules, ribose molecules, gulose molecules, fucose molecules, galactose molecules, maltose molecules, lactose molecules, phosphates, phosphonates, phenylureas, thioureas, nitroimidazoles , amines, benzamides, isocyanates, nicotinamides, or azulenes. 
     
     
       3. The method of treating, a biological tissue using a proton beam according to  claim 1 , wherein the proton beam irradiates the biological tissue in a spot scanning manner, uniform scanning manner, fast scanning manner, or scatter manner. 
     
     
       4. The method of treating a biological tissue using a proton beam according to  claim 1 , wherein the proton beam obtains appropriate energy and transmits to the biological tissue by cyclotron or synchrotron. 
     
     
       5. The method of treating a biological tissue using a proton beam according to  claim 1 , wherein the reactant is introduced into the biological tissue by a catheter or a drug carrier. 
     
     
       6. The method of treating biological tissues using a proton beam according to  claim 1 , wherein the reactant is introduced into the biological tissue in an intramuscular manner, intravenous manner, oral manner, or subcutaneous manner. 
     
     
       7. The method of treating biological tissues using a proton beam according to  claim 6 , wherein the intravenous manner comprises an intravenous infusion admixture, an intravenous drip, or an intravenous push.