US10149904B2ActiveUtilityA1

Mixed allergen compositions and methods for using the same

Assignee: UNIV LELAND STANFORD JUNIORPriority: Feb 20, 2015Filed: Jul 29, 2016Granted: Dec 11, 2018
Est. expiryFeb 20, 2035(~8.6 yrs left)· nominal 20-yr term from priority
Inventors:Kari C. Nadeau
A61K 2039/542A61K 2039/55A61K 47/46A61K 2039/575A61K 2039/70A61K 45/06A61K 2039/572A61K 39/35A61K 35/60A61K 2035/115A61K 47/44A61K 35/747A61K 2039/57A61K 9/148A61K 9/0053A61K 2039/54
96
PatentIndex Score
16
Cited by
114
References
18
Claims

Abstract

Mixed allergen compositions of one, two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method for treating one or more food allergies in a human subject with an existing food allergy to one or more foods, the method comprising administering to the subject a mixed allergen composition comprising 2 to 20 different flours or powders, wherein at least one flour or powder is a nut flour selected from the group consisting of peanut, almond, walnut, cashew, hazelnut, pecan, and pistachio, at least one flour or powder is an animal powder selected from the group consisting of shrimp, cod, and salmon, and the mixed allergen composition comprises equal parts by protein weight of each flour or powder, and wherein the composition is administered to the subject at least weekly or at least every other week. 
     
     
       2. The method of  claim 1 , further comprising allowing sufficient time for the administration of the composition to inhibit symptoms of food allergy in the human subject. 
     
     
       3. The method  claim 1 , wherein the one or more food allergies is a single food allergy. 
     
     
       4. The method of  claim 1 , wherein the one or more food allergies is a multiple food allergy. 
     
     
       5. The method of  claim 1 , wherein the 2 to 20 different flours or powders are each selected from the group consisting of shellfish, peanut, tree nut, fish, milk, egg, legume, grain, sesame, and fruit. 
     
     
       6. The method of  claim 5 , wherein the 2 to 20 different flours or powders are each selected from the group consisting of cashew, pistachio, walnut, almond, pecan, chicken egg, cow milk, peanut, shrimp, salmon, wheat, cod, crab, legume, and seed. 
     
     
       7. The method of  claim 1 , wherein the administration of the composition significantly inhibits the symptoms of a food allergy in the subject as compared to administering to the subject a composition that includes only one flour or powder. 
     
     
       8. The method of  claim 1 , wherein the human subject is a pediatric subject. 
     
     
       9. The method of  claim 1 , wherein the human subject is an adult. 
     
     
       10. The method of  claim 1 , wherein the composition is administered orally, nasally, topically or subcutaneously. 
     
     
       11. The method of  claim 1 , wherein the composition is a food product. 
     
     
       12. The method of  claim 11 , wherein the food product is a baked food product. 
     
     
       13. The method of  claim 1 , wherein at least one flour or powder is a non-nut plant flour selected from the group consisting of wheat, sesame, and oat. 
     
     
       14. The method of  claim 1 , wherein at least one flour or powder is powdered hen's egg. 
     
     
       15. The method of  claim 1 , wherein at least one flour or powder is soy. 
     
     
       16. The method of  claim 1 , wherein the mixed allergen composition comprises vitamin D. 
     
     
       17. The method of  claim 10 , wherein the composition is administered orally. 
     
     
       18. A method for treating one or more food allergies in a human subject with an existing food allergy to one or more foods, the method comprising orally administering to the subject a mixed allergen unit composition comprising:
 6 to 20 different flours or powders, 
 wherein at least one flour or powder is a nut flour selected from the group consisting of peanut, almond, walnut, cashew, hazelnut, pecan, and pistachio, 
 at least one flour or powder is an animal powder selected from the group consisting of shrimp, cod, salmon, milk, and egg, 
 at least one flour or powder is a non-nut plant flour selected from the group consisting of wheat, sesame, and oat, and 
 the unit composition comprises equal parts by protein weight of each flour or powder.

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