Preparations for suppressing or attenuating ocular irritancy

Abstract

Provided is a tear-free formulation for suppressing or reducing ocular irritancy of a pre-made cosmetic or therapeutic formulation or an ophthalmic formulation suitable for application to an eye of a subject or to a skin region surrounding an eye of a subject.

The invention claimed is: 
     
       1. A method for reducing, diminishing or ameliorating irritation to an eye region or to a skin region surrounding the eye, the method comprising topically administering to the eye region or to the skin region surrounding the eye a formulation selected from the group consisting of:
 (i) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and sodium hyaluronate; 
 (ii) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan; 
 (iii) soy-bean lecithin, jojoba oil, squalene oil, egg yolk and at least one polyol selected from mannitol, glycerol, zemea and trehalose; and 
 (iv) soy-bean lecithin, jojoba oil, squalene oil, egg yolk, at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan, and at least one polyol selected from mannitol, glycerol, zemea and trehalose. 
 
     
     
       2. The method according to  claim 1 , wherein the formulation is selected from the group consisting of (A) a baby shampoo, baby bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human infant skin; or from the group consisting of (B) adult shampoo, adult bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human adult skin. 
     
     
       3. The method according to  claim 1 , wherein the formulation further comprising at least one additional additive selected from the group consisting of phospholipids, polysaccharides, polyols, saponins, salicilates, preservatives, perfumes, natural coloring agents, emollients, non-aqueous or aqueous solvents or mixtures, and other active or non-active components. 
     
     
       4. The method according to  claim 1 , wherein the formulation further comprising at least one preservative. 
     
     
       5. The method according to  claim 1 , wherein the formulation further comprising at least one saponin. 
     
     
       6. A method of reducing, diminishing or ameliorating irritation to an eye region or to a skin region surrounding the eye, said irritation being associated with at least one skin care formulation, the method comprising adding on to said skin care formulation a formulation according to  claim 1  to obtain an add on formulation, wherein said skin care formulation is selected from the group consisting of (A) a baby shampoo, baby bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human infant skin; or from the group consisting of (B) adult shampoo, adult bath, mild skin cleanser, facial skin cleanser, sensitive skin cleanser and cleansing formulations suitable for use on human adult skin. 
     
     
       7. The method according to  claim 6 , wherein the add on formulation comprises at least one saponin selected from the group consisting of  Sapindus mukorossi  extract,  Camellia oleifera  extract and  Quillaja  extract; Aspen bark extract; soy-bean lecithin; Jojoba oil; Squalene oil; Egg yolk; at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan; and at least one polyol selected from mannitol, glycerol, zemea and trehalose. 
     
     
       8. A method for suppressing or reducing ocular irritancy of a pre-made cosmetic or therapeutic formulation or an ophthalmic formulation suitable for application to an eye of a subject or to a skin region surrounding an eye of a subject, the cosmetic or therapeutic formulation being capable of causing irritation to an ocular membrane or to the eye's cornea, the method comprising adding on to said pre-made cosmetic or therapeutic formulation or an ophthalmic formulation a formulation according to  claim 1 . 
     
     
       9. The method of  claim 6 , wherein the add on formulation comprises  Sapindus mukorossi  extract,  Camellia oleifera  extract,  Quillaja  extract, Aspen bark extract, soy-bean lecithin, jojoba oil, squalene oil, egg yolk, at least one polysaccharide selected from sodium hyaluronate, xanthan gum and carrageenan; and at least one polyol selected from mannitol, glycerol, zemea and trehalose. 
     
     
       10. The method of  claim 6 , wherein the add on formulation comprises 0.5-6 wt % of  Sapindus mukorossi  extract; 0.1-6 wt % of  Camellia oleifera  extract; 0.1-6 wt % of  Quillaja  extract; 0.1-0.8 wt % of Aspen bark extract; 0.1-5 wt % of soy-bean lecithin; 0.2-4 wt % of jojoba oil; 0.2-4 wt % of squalene oil; 0.2-5 wt % of egg yolk; at least one polysaccharide selected from sodium hyaluronate up to 0.8 wt %, xanthan gum up to 2.5 wt % and carrageenan up to 2.5 wt %; at least one polyol selected from mannitol up to 2.5 wt % and glycerol up to 2.5 wt %, and optionally zemea up to 15 wt % and/or trehalose up to 2.5 wt %; and optionally perfume up to 1.5 wt %.