Topic leaderboard
Enzyme / nucleic-acid measuring & testing
Ranked by the PatentIndex Score — a 1–99 percentile within C12Q · public-visibility date · generated 2026
top 25 per window · public-visibility date
Rising· last 2 yrs
Inventors whose newest C12Q patents became public in the last 2 years — the current frontier
- 199Jan Berka16 patents · 3,892 citations
- 296James Bustillo70 patents · 3,406 citations
- 392Jingyue Ju97 patents · 6,140 citations
- 488Zengmin Li49 patents · 1,997 citations
- 583Serge Saxonov77 patents · 5,454 citations
- 679Michael Schnall-Levin83 patents · 4,848 citations
- 775Jonas Frisen20 patents · 2,517 citations
- 871Patrik Stahl18 patents · 2,345 citations
- 967Amirali Talasaz94 patents · 1,781 citations
- 1063Mirna Jarosz49 patents · 3,136 citations
- 1158Christopher Hindson48 patents · 3,241 citations
- 1254Justin T. Mason7 patents · 1,817 citations
- 1350Randy P. Rasmussen18 patents · 1,941 citations
- 1446Snezana Drmanac29 patents · 1,568 citations
- 1542Matthew J. Callow27 patents · 1,374 citations
- 1638Brian K. Hauser12 patents · 1,255 citations
- 1733Niall A. Armes41 patents · 2,347 citations
- 1829Gurdial Singh Sanghera15 patents · 3,093 citations
- 1925Olaf Piepenburg37 patents · 1,771 citations
- 2021Mark A. Akeson29 patents · 1,951 citations
- 2117Jene A. Golovchenko23 patents · 1,571 citations
- 2213Helmy Eltoukhy84 patents · 1,715 citations
- 238Rajiv Bharadwaj49 patents · 1,621 citations
- 244George Yeung14 patents · 897 citations
- 251Russell Higuchi21 patents · 2,150 citations
Active· last 5 yrs
Sustained C12Q output across the last 5 years
- 199Randall K. Saiki24 patents · 25,157 citations
- 296Jennifer Rinehart11 patents · 6,504 citations
- 392Marianne Malven14 patents · 6,624 citations
- 488Ellen Dickinson7 patents · 5,259 citations
- 583Nancy Taylor7 patents · 5,259 citations
- 679Jan Berka16 patents · 3,892 citations
- 775Sanjay Tyagi23 patents · 5,267 citations
- 871Rustem F. Ismagilov49 patents · 1,827 citations
- 967James Bustillo70 patents · 3,406 citations
- 1063Jingyue Ju97 patents · 6,140 citations
- 1158Zengmin Li49 patents · 1,997 citations
- 1254Paul Hardenbol41 patents · 3,876 citations
- 1350Serge Saxonov77 patents · 5,454 citations
- 1446Michael Schnall-Levin83 patents · 4,848 citations
- 1542Harold Philip Swerdlow21 patents · 3,042 citations
- 1638David A. Routenberg17 patents · 1,737 citations
- 1733Jonas Frisen20 patents · 2,517 citations
- 1829Patrik Stahl18 patents · 2,345 citations
- 1925Christina Fan30 patents · 2,161 citations
- 2021Andrew Slatter28 patents · 1,325 citations
- 2117Chad A. Mirkin55 patents · 4,888 citations
- 2213Robert C. Mucic38 patents · 4,076 citations
- 238Jian-Bing Fan34 patents · 3,629 citations
- 244Amirali Talasaz94 patents · 1,781 citations
- 251Mirna Jarosz49 patents · 3,136 citations
All-time canon
Career PatentIndex Score in C12Q
- 199Ephraim Heller111 patents · 26,000 citations
- 296Phillip John Plante70 patents · 18,537 citations
- 392Yoram Gal70 patents · 18,537 citations
- 488Behrad Aria66 patents · 18,414 citations
- 583Fredric C. Colman94 patents · 14,691 citations
- 679Keith A. Friedman43 patents · 7,027 citations
- 775Lubert Stryer36 patents · 19,331 citations
- 871J. Leighton Read29 patents · 18,080 citations
- 967Michael C. Pirrung29 patents · 18,080 citations
- 1063Joseph A. Vivolo44 patents · 7,466 citations
- 1158Rajesh Krishnan42 patents · 7,463 citations
- 1254Randall K. Saiki24 patents · 25,157 citations
- 1350Jennifer Rinehart11 patents · 6,504 citations
- 1446Willem P. Stemmer9 patents · 7,838 citations
- 1542Marianne Malven14 patents · 6,624 citations
- 1638Rathbun K. Rhodes30 patents · 11,792 citations
- 1733Sharon Kaye Spratt8 patents · 3,914 citations
- 1829Stuart J. Updike21 patents · 11,594 citations
- 1925Henry A. Erlich24 patents · 22,015 citations
- 2021James E. Summerton12 patents · 13,935 citations
- 2117Ellen Dickinson7 patents · 5,259 citations
- 2213Nancy Taylor7 patents · 5,259 citations
- 238David H. Gelfand41 patents · 12,758 citations
- 244Glenn T. Horn12 patents · 20,074 citations
- 251Robert J. Jones16 patents · 7,911 citations
Rising· last 2 yrs
The top-scoring C12Q patents made public in the last 2 years
- 199US11933957B1✦ AIImaging system hardware47 cites · 202475% earned
- 296US11970739B2✦ AIMultiplex capture of gene and protein expression from a biological sample45 cites · 202485% earned
- 392US12098417B2✦ AISpatial transcriptomics for antigen-receptors36 cites · 202482% earned
- 488US12117439B2Compositions and methods for using fixed biological samples34 cites · 202484% earned
- 583US12234505B2Spatially encoded biological assays21 cites · 202462% earned
- 679US11926822B1Three-dimensional spatial analysis48 cites · 202492% earned
- 775US11926863B1Solid state single cell method for analyzing fixed biological cells46 cites · 202488% earned
- 871US11981960B1Spatial analysis utilizing degradable hydrogels43 cites · 202487% earned
- 967US11981958B1Methods for spatial analysis using DNA capture43 cites · 202487% earned
- 1063US12031177B1Methods of enhancing spatial resolution of transcripts41 cites · 202487% earned
- 1158US12275988B2Methods, compositions, and kits for determining the location of an analyte in a biological16 cites · 202484% earned
- 1254US12440837B2Devices and methods for analyzing biological samples7 cites · 202564% earned
- 1350US12209280B1Methods of identifying abundance and location of an analyte in a biological sample using s27 cites · 202586% earned
- 1446US12270077B2Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological 16 cites · 202473% earned
- 1542US12286673B2Increasing efficiency of spatial analysis in a biological sample15 cites · 202480% earned
- 1638US12169198B2Systems and methods for sample analysis15 cites · 202483% earned
- 1733US12203142B2Detecting mutations and ploidy in chromosomal segments9 cites · 202460% earned
- 1829US11987838B2Methods and kits for labeling cellular molecules13 cites · 202461% earned
- 1925US12371688B2Methods, compositions, and systems for spatial analysis of analytes in a biological sample8 cites · 202468% earned
- 2021US12066369B2Synthetic human cell mimic particle for cytometric or coulter device7 cites · 202464% earned
- 2117US12281357B1In situ spatial barcoding16 cites · 202589% earned
- 2213US12442045B2Methods of detecting spatial heterogeneity of a biological sample6 cites · 202478% earned
- 238USRE50065EMethods and product for optimising localised or spatial detection of gene expression in a 39 cites · 202487% earned
- 244US12084715B1Methods and systems for reducing artifactual antisense products14 cites · 202489% earned
- 251US12259394B2Protein sequencing via coupling of polymerizable molecules5 cites · 202469% earned
Active· last 5 yrs
The top-scoring C12Q patents of the last 5 years
- 199US11332790B2✦ AIMethods for spatial analysis using RNA-templated ligation173 cites · 202181% earned
- 296US11162132B2✦ AISpatially distinguished, multiplex nucleic acid analysis of biological specimens146 cites · 202181% earned
- 392US11408029B2✦ AISpatial analysis of DNA methylation116 cites · 202286% earned
- 488US11046996B1Methods and systems for determining spatial patterns of biological targets in a sample143 cites · 202179% earned
- 583US11352659B2Methods of detecting analytes139 cites · 202278% earned
- 679US11519033B2Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological 108 cites · 202282% earned
- 775US11512308B2Nucleic acid library methods108 cites · 202284% earned
- 871US11618897B2Methods, compositions, and systems for capturing probes and/or barcodes97 cites · 202282% earned
- 967US11592447B2Spatially-tagged analyte capture agents for analyte multiplexing96 cites · 202285% earned
- 1063US11067567B2Spatially encoded biological assays119 cites · 202176% earned
- 1158US11407992B2Methods of determining a surgical margin and methods of use thereof116 cites · 202284% earned
- 1254US11753673B2Methods, compositions, and kits for blocking a capture probe on a spatial array69 cites · 202386% earned
- 1350US11434524B2Methods for determining a location of an analyte in a biological sample113 cites · 202290% earned
- 1446US11535887B2Methods for spatial analysis using targeted RNA depletion104 cites · 202287% earned
- 1542US11008607B2Spatially encoded biological assays124 cites · 202172% earned
- 1638US11702698B2Enhancing specificity of analyte binding80 cites · 202289% earned
- 1733US11560592B2Method for resetting an array100 cites · 202289% earned
- 1829US11608520B2Spatial analysis to detect sequence variants98 cites · 202287% earned
- 1925US11624086B2Simultaneous spatio-temporal measurement of gene expression and cellular activity93 cites · 202287% earned
- 2021US11739381B2Multiplex capture of gene and protein expression from a biological sample72 cites · 202286% earned
- 2117US11649485B2Generating capture probes for spatial analysis90 cites · 202189% earned
- 2213US11692218B2Spatial transcriptomics for antigen-receptors80 cites · 202285% earned
- 238US11926867B2Generating capture probes for spatial analysis48 cites · 202385% earned
- 244US11933957B1Imaging system hardware47 cites · 202475% earned
- 251US11702693B2Methods for printing cells and generating arrays of barcoded cells78 cites · 202189% earned
All-time canon
The defining C12Q patents of the whole record
- 199US4683202A✦ AIProcess for amplifying nucleic acid sequences13,211 cites · 198796% earned
- 296US4683195A✦ AIProcess for amplifying, detecting, and/or-cloning nucleic acid sequences11,047 cites · 198796% earned
- 392US4965188A✦ AIProcess for amplifying, detecting, and/or cloning nucleic acid sequences using a thermosta3,972 cites · 199096% earned
- 488US4800159AProcess for amplifying, detecting, and/or cloning nucleic acid sequences3,941 cites · 198996% earned
- 583US6175752B1Analyte monitoring device and methods of use3,859 cites · 200178% earned
- 679US5143854ALarge scale photolithographic solid phase synthesis of polypeptides and receptor binding s3,709 cites · 199285% earned
- 775US5034506AUncharged morpholino-based polymers having achiral intersubunit linkages3,553 cites · 199196% earned
- 871US5445934AArray of oligonucleotides on a solid substrate3,129 cites · 199584% earned
- 967US5744305AArrays of materials attached to a substrate3,038 cites · 199887% earned
- 1063US5593852ASubcutaneous glucose electrode2,475 cites · 199782% earned
- 1158US6565509B1Analyte monitoring device and methods of use2,432 cites · 200377% earned
- 1254US6210891B1Method of sequencing DNA2,281 cites · 200196% earned
- 1350US7632985B2Soybean event MON89788 and methods for detection thereof2,183 cites · 200685% earned
- 1446US6120676AMethod of using a small volume in vitro analyte sensor2,157 cites · 200083% earned
- 1542US6103033AProcess for producing an electrochemical biosensor2,151 cites · 200085% earned
- 1638US6134461AElectrochemical analyte2,150 cites · 200087% earned
- 1733US5210015AHomogeneous assay system using the nuclease activity of a nucleic acid polymerase2,135 cites · 199389% earned
- 1829US8697359B1CRISPR-Cas systems and methods for altering expression of gene products2,109 cites · 201487% earned
- 1925US5605793AMethods for in vitro recombination2,091 cites · 199785% earned
- 2021US5539082APeptide nucleic acids2,083 cites · 199693% earned
- 2117US5235033AAlpha-morpholino ribonucleoside derivatives and polymers thereof2,054 cites · 199396% earned
- 2213US5837458AMethods and compositions for cellular and metabolic engineering2,016 cites · 199893% earned
- 238US5185444AUncharged morpolino-based polymers having phosphorous containing chiral intersubunit linka2,014 cites · 199396% earned
- 244US5854033ARolling circle replication reporter systems1,960 cites · 199889% earned
- 251US6514718B2Subcutaneous glucose electrode1,958 cites · 200282% earned
Rising· last 2 yrs
Assignees whose newest C12Q patents became public in the last 2 years — the current frontier
- 199ABBOTT DIABETES CARE INC150 patents · 7,658 citations
- 296DEXCOM INC80 patents · 16,527 citations
- 392MONSANTO TECHNOLOGY LLC287 patents · 9,343 citations
- 488UNIV CALIFORNIA1,034 patents · 40,020 citations
- 583BROAD INST INC172 patents · 6,054 citations
- 679CALIFORNIA INST OF TECHN260 patents · 19,111 citations
- 775SEQUENOM INC122 patents · 12,470 citations
- 871GEN PROBE INC505 patents · 19,039 citations
- 967UNIV LELAND STANFORD JUNIOR402 patents · 12,956 citations
- 1063BECTON DICKINSON CO331 patents · 17,746 citations
- 1158HARVARD COLLEGE390 patents · 17,337 citations
- 1254ILLUMINA INC534 patents · 10,583 citations
- 1350UNIV JOHNS HOPKINS336 patents · 8,448 citations
- 1446UNIV COLUMBIA216 patents · 5,799 citations
- 1542ILLUMINA CAMBRIDGE LTD210 patents · 4,746 citations
- 1638ROCHE MOLECULAR SYSTEMS INC288 patents · 5,933 citations
- 1733PROGNOSYS BIOSCIENCES INC71 patents · 5,273 citations
- 1829UNIV UTAH RES FOUND129 patents · 4,608 citations
- 1925MASSACHUSETTS INST TECHNOLOGY208 patents · 7,505 citations
- 2021GENENTECH INC404 patents · 4,927 citations
- 211710X GENOMICS INC314 patents · 12,915 citations
- 2213LUMINEX CORP69 patents · 3,427 citations
- 238SCRIPPS RESEARCH INST61 patents · 3,427 citations
- 244GUARDANT HEALTH INC126 patents · 1,823 citations
- 251ENZO BIOCHEM INC33 patents · 3,361 citations
Active· last 5 yrs
Sustained C12Q output across the last 5 years
- 199ABBOTT DIABETES CARE INC150 patents · 7,658 citations
- 296AFFYMETRIX INC275 patents · 36,114 citations
- 392DEXCOM INC80 patents · 16,527 citations
- 488MONSANTO TECHNOLOGY LLC287 patents · 9,343 citations
- 583UNIV CALIFORNIA1,034 patents · 40,020 citations
- 679UNIV PENNSYLVANIA145 patents · 12,806 citations
- 775GILEAD SCIENCES INC64 patents · 14,182 citations
- 871UNIV IOWA RES FOUND81 patents · 7,904 citations
- 967BROAD INST INC172 patents · 6,054 citations
- 1063CALIFORNIA INST OF TECHN260 patents · 19,111 citations
- 1158SEQUENOM INC122 patents · 12,470 citations
- 1254GEN PROBE INC505 patents · 19,039 citations
- 1350UNIV YALE134 patents · 10,834 citations
- 1446UNIV LELAND STANFORD JUNIOR402 patents · 12,956 citations
- 1542BECTON DICKINSON CO331 patents · 17,746 citations
- 1638HOFFMANN LA ROCHE126 patents · 12,020 citations
- 1733HARVARD COLLEGE390 patents · 17,337 citations
- 1829ILLUMINA INC534 patents · 10,583 citations
- 1925UNIV JOHNS HOPKINS336 patents · 8,448 citations
- 2021ABBOTT LAB180 patents · 12,245 citations
- 2117UNIV COLUMBIA216 patents · 5,799 citations
- 2213MAX PLANCK GESELLSCHAFT53 patents · 2,262 citations
- 238ILLUMINA CAMBRIDGE LTD210 patents · 4,746 citations
- 244ROCHE MOLECULAR SYSTEMS INC288 patents · 5,933 citations
- 251PROGNOSYS BIOSCIENCES INC71 patents · 5,273 citations
All-time canon
All-time PatentIndex Score in C12Q
- 199THERASENSE INC35 patents · 42,869 citations
- 296AFFYMAX TECH NV22 patents · 21,679 citations
- 392HELLER E & CO11 patents · 17,124 citations
- 488ABBOTT DIABETES CARE INC150 patents · 7,658 citations
- 583CETUS CORP20 patents · 35,314 citations
- 679AFFYMETRIX INC275 patents · 36,114 citations
- 775SANGAMO BIOSCIENCES INC28 patents · 6,830 citations
- 871DEXCOM INC80 patents · 16,527 citations
- 967ANTI GENE DEV GROUP7 patents · 11,850 citations
- 1063CORNELL RES FOUNDATION INC88 patents · 10,645 citations
- 1158ISIS PHARMACEUTICALS INC202 patents · 25,301 citations
- 1254MONSANTO TECHNOLOGY LLC287 patents · 9,343 citations
- 1350UNIV CALIFORNIA1,034 patents · 40,020 citations
- 1446UNIV PENNSYLVANIA145 patents · 12,806 citations
- 1542GILEAD SCIENCES INC64 patents · 14,182 citations
- 1638UNIV IOWA RES FOUND81 patents · 7,904 citations
- 1733BROAD INST INC172 patents · 6,054 citations
- 1829LYNX THERAPEUTICS INC40 patents · 12,292 citations
- 1925MAXYGEN INC51 patents · 15,657 citations
- 2021CALIFORNIA INST OF TECHN260 patents · 19,111 citations
- 2117454 LIFE SCIENCES CORP20 patents · 5,951 citations
- 2213SOLEXA LTD6 patents · 6,080 citations
- 238CHIRON CORP122 patents · 16,341 citations
- 244SEQUENOM INC122 patents · 12,470 citations
- 251GEN PROBE INC505 patents · 19,039 citations
90–99 field-defining50–89 strong<50 emergingearned by citationsfrom family breadth