Inventor · disambiguated record
Darell Bigner
Also filed as: BIGNER DARELL · BIGNER DARELL D
55 granted patents·32 pending applications·1,007 citations·filing 1990–2025
98Inventor score
Top patents by PatentIndex Score
87 records- 0197US5212290AAntibodies specific for type II mutant EGTRUNIV JOHNS HOPKINS·Filed 1990·Granted May 18, 1993·318 cites·3 claims
- 0296US10704108B2Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2018·Granted Jul 7, 2020·22 cites·16 claims
- 0394US10837064B2Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2018·Granted Nov 17, 2020·9 cites·14 claims
- 0494US5624659AMethod of treating brain tumors expressing tenascinUNIV DUKE·Filed 1995·Granted Apr 29, 1997·144 cites·21 claims
- 0593US8685660B2Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaVOGELSTEIN BERT·Filed 2009·Granted Apr 1, 2014·21 cites·14 claims
- 0693US6455498B1Structural alterations of the EGF receptor genes in human tumorsUNIV JOHNS HOPKINS·Filed 2000·Granted Sep 24, 2002·46 cites·12 claims
- 0792US11813298B2Oncolytic poliovirus for human tumorsUNIV DUKE·Filed 2022·Granted Nov 14, 2023·1 cites·18 claims
- 0892US11406677B2Oncolytic poliovirus for human tumorsUNIV DUKE·Filed 2020·Granted Aug 9, 2022·3 cites·25 claims
- 0992US10799543B2Oncolytic poliovirus for human tumorsUNIV DUKE·Filed 2019·Granted Oct 13, 2020·4 cites·31 claims
- 1091US10894987B2Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2016·Granted Jan 19, 2021·5 cites·8 claims
- 1191US9353418B2Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2013·Granted May 31, 2016·13 cites·24 claims
- 1290US5401828AStructural alterations of the EGF receptor gene in human gliomasUNIV JOHNS HOPKINS·Filed 1992·Granted Mar 28, 1995·62 cites·12 claims
- 1390US2024392381A1Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2024·Application pending·0 cites
- 1488US10398743B2Oncolytic poliovirus for human tumorsUNIV DUKE·Filed 2017·Granted Sep 3, 2019·5 cites·22 claims
- 1588US8039593B2Antibodies and immunotoxins that target human glycoprotein NMBUNIV DUKE·Filed 2006·Granted Oct 18, 2011·10 cites·32 claims
- 1687US8541568B2Compositions and methods using siRNA molecules for treatment of gliomasYAN HAI·Filed 2009·Granted Sep 24, 2013·11 cites·16 claims
- 1787US7129332B2Anti-EGFRvIII scFvs with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereofUS HEALTH·Filed 2001·Granted Oct 31, 2006·29 cites·30 claims
- 1884US9249217B2Bispecific EGFRvIII x CD3 antibody engaging moleculesBIGNER DARELL D·Filed 2011·Granted Feb 2, 2016·10 cites·6 claims
- 1983US10072084B2Dual specific immunotoxin for brain tumor therapyUNIV DUKE·Filed 2016·Granted Sep 11, 2018·2 cites·13 claims
- 2081US11331343B2Compositions and methods for activating antigen presenting cells with chimeric poliovirusUNIV DUKE·Filed 2017·Granted May 17, 2022·1 cites·34 claims
- 2181US9873917B2Oligodendroglioma drive genesVOGELSTEIN BERT·Filed 2012·Granted Jan 23, 2018·2 cites·5 claims
- 2281US6127126AMethod for diagnosing glioma associated with structural alterations of the EGF receptor gene in human tumorsUNIV JOHNS HOPKINS·Filed 1999·Granted Oct 3, 2000·57 cites·6 claims
- 2380US2024415906A1Combination TreatmentUNIV DUKE·Filed 2023·Application pending·0 cites
- 2479US5981725AStructural alterations of the EGF receptor gene in human tumorsJOHNS HOPKINS UNIVIERSITY·Filed 1995·Granted Nov 9, 1999·58 cites·12 claims
- 2579US5814317AStructural alterations of the EGF receptor gene in human gliomasUNIV JOHNS HOPKINS·Filed 1995·Granted Sep 29, 1998·39 cites·10 claims
- 2678US9492564B2Dual specific immunotoxin for brain tumor therapyUNIV DUKE·Filed 2014·Granted Nov 15, 2016·2 cites·17 claims
- 2778US5710010AAssays for the presence of a mutant EGF receptorUNIV JOHNS HOPKINS·Filed 1995·Granted Jan 20, 1998·42 cites·7 claims
- 2876US11065332B2Combination therapy of immunotoxin and checkpoint inhibitorUNIV DUKE·Filed 2016·Granted Jul 20, 2021·1 cites·22 claims
- 2976US10711310B2Tert promoter mutations in gliomas and a subset of tumorsUNIV DUKE·Filed 2014·Granted Jul 14, 2020·1 cites·38 claims
- 3076US10053514B2Human bispecific EGFRvIII and CD3 antibody engaging moleculesUNIV DUKE·Filed 2014·Granted Aug 21, 2018·3 cites·8 claims
- 3176US2024350624A1Combination Therapy of Immunotoxin and Checkpoint InhibitorUNIV DUKE·Filed 2024·Application pending·0 cites
- 3275US2021317532A1Genetic alterations in isocitrate dehydrogenase and other genes in malignant gliomaUNIV JOHNS HOPKINS·Filed 2020·Application pending·0 cites
- 3374US9695479B2Medulloblastoma genes as targets for diagnosis and therapeuticsVOGELSTEIN BERT·Filed 2011·Granted Jul 4, 2017·2 cites·17 claims
- 3473US11311628B2Production of immunotoxin D2C7—(scdsFv)—PE38KDELUNIV DUKE·Filed 2017·Granted Apr 26, 2022·1 cites·6 claims
- 3572US2025241969A1Neoadjuvant cancer treatmentUNIV DUKE·Filed 2025·Application pending·0 cites
- 3668US5695751AEnhancing delivery of large neutral amino acid drugsCORNELL RES FOUNDATION INC·Filed 1995·Granted Dec 9, 1997·21 cites·22 claims
- 3768US5558852AMethods of treating melanomas and gliomas with monoclonal antibody Me1-14UNIV DUKE·Filed 1994·Granted Sep 24, 1996·34 cites·28 claims
- 3867US2011217231A1Anti-tenascin monoclonal antibody therapy for lymphomaUNIV DUKE·Filed 2007·Application pending·0 cites
- 3966US2009269343A1Dual Specific Immunotoxin for Brain Tumor TherapyUNIV DUKE·Filed 2009·Application pending·0 cites
- 4066US2015118181A1Concurrent Chemotherapy and ImmunotherapySAMPSON JOHN H·Filed 2014·Application pending·0 cites
- 4165US9399662B2Concurrent chemotherapy and immunotherapySAMPSON JOHN H·Filed 2006·Granted Jul 26, 2016·0 cites·2 claims
- 4265US2021338811A1Combination Therapy of Immunotoxin and Checkpoint InhibitorUNIV DUKE·Filed 2021·Application pending·0 cites
- 4363US11428691B2Methods for predicting tumor response to immunotherapyUNIV DUKE·Filed 2019·Granted Aug 30, 2022·0 cites·15 claims
- 4463US11254988B2Somatic mutations in ATRX in brain cancerUNIV JOHNS HOPKINS·Filed 2018·Granted Feb 22, 2022·0 cites·7 claims
- 4563US10619217B2Oligodendroglioma drive genesUNIV JOHNS HOPKINS·Filed 2017·Granted Apr 14, 2020·0 cites·6 claims
- 4663US2021106633A1Neoadjuvant cancer treatmentUNIV DUKE·Filed 2019·Application pending·0 cites
- 4762US2006257317A1Combination therapy in the treatment of cancerUNIV DUKE·Filed 2006·Application pending·0 cites
- 4861US8900816B2Assay for anti-EGFRvIII antibodiesSCHMITTLING ROBERT J·Filed 2008·Granted Dec 2, 2014·3 cites·16 claims
- 4961US2013022598A1Dual Specific Immunotoxin for Brain Tumor TherapyUS SECRETARY DEPT OF HEALTH AND HUMAN SERVICE·Filed 2012·Application pending·0 cites
- 5061US2016030497A1Oncolytic poliovirus for human tumorsUNIV DUKE·Filed 2013·Application pending·0 cites
Showing the top 50 of 87 patent records by PatentIndex Score.
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