Inventor · disambiguated record
Thomas W. Bruice
Also filed as: BRUICE THOMAS · BRUICE THOMAS W · BRUICE THOMAS WAYNE
23 granted patents·1 pending application·1,309 citations·filing 1991–2007
97Inventor score
Top patents by PatentIndex Score
24 records- 0196US7807653B2Nucleotide mimics and their prodrugsBIOTA SCIENT MANAGEMENT·Filed 2007·Granted Oct 5, 2010·86 cites·28 claims
- 0295US7598230B2Nucleotide mimics and their prodrugsBIOTA SCIENT MANAGEMENT·Filed 2007·Granted Oct 6, 2009·94 cites·33 claims
- 0394US5686242ADetermination of oligonucleotides for therapeutics, diagnostics and research reagentsISIS PHARMACEUTICALS INC·Filed 1994·Granted Nov 11, 1997·157 cites·77 claims
- 0493US7285658B2Nucleotide mimics and their prodrugsBIOTA INC·Filed 2003·Granted Oct 23, 2007·146 cites·10 claims
- 0593US5514786ACompositions for inhibiting RNA activityISIS PHARMACEUTICALS INC·Filed 1992·Granted May 7, 1996·108 cites·21 claims
- 0690US6423489B1Compositions and methods for treatment of Hepatitis C virus-associated diseasesISIS PHARMACEUTICALS INC·Filed 1995·Granted Jul 23, 2002·120 cites·7 claims
- 0790US5719271ACovalently cross-linked oligonucleotidesISIS PHARMACEUTICALS INC·Filed 1994·Granted Feb 17, 1998·114 cites·22 claims
- 0888US5543507ACovalently cross-linked oligonucleotidesISIS PHARMACEUTICALS INC·Filed 1994·Granted Aug 6, 1996·92 cites·77 claims
- 0985US6358931B1Compositions and methods for modulating RNAISIS PHARMACEUTICALS INC·Filed 1993·Granted Mar 19, 2002·75 cites·50 claims
- 1083US6391542B1Compositions and methods for treatment of Hepatitis C virus-associated diseasesISIS PHARMACEUTICALS INC·Filed 1996·Granted May 21, 2002·95 cites·8 claims
- 1181US5359051ACompounds useful in the synthesis of nucleic acids capable of cleaning RNAISIS PHARMACEUTICALS INC·Filed 1992·Granted Oct 25, 1994·59 cites·2 claims
- 1280US7189506B1DNA binding compound-mediated molecular switch systemGENELABS TECH INC·Filed 2000·Granted Mar 13, 2007·12 cites·6 claims
- 1378US6610663B2Compositions and methods for modulating RNAISIS PHARMACEUTICALS INC·Filed 2001·Granted Aug 26, 2003·4 cites·6 claims
- 1472US5698391AMethods for synthetic unrandomization of oligomer fragmentsISIS PHARMACEUTICALS INC·Filed 1994·Granted Dec 16, 1997·36 cites·80 claims
- 1567US5736294AReagents and methods for modulating gene expression through RNA mimicryISIS PHARMACEUTICALS INC·Filed 1991·Granted Apr 7, 1998·22 cites·14 claims
- 1666US6022691ADetermination of oligonucleotides for therapeutics, diagnostics and research reagentsISIS PHARMACEUTICALS INC·Filed 1997·Granted Feb 8, 2000·25 cites·7 claims
- 1765US5874564AReagents and methods for modulating gene expression through RNA mimicryISIS PHARMACEUTICALS INC·Filed 1995·Granted Feb 23, 1999·25 cites·15 claims
- 1861US6838556B2Promoters for regulated gene expressionGENELABS TECH INC·Filed 2001·Granted Jan 4, 2005·1 cites·1 claims
- 1960US6355428B1Nucleic acid ligand interaction assaysGENELABS TECH INC·Filed 1999·Granted Mar 12, 2002·20 cites·38 claims
- 2046US5672472ASynthetic unrandomization of oligomer fragmentsISIS PHARMACEUTICALS INC·Filed 1992·Granted Sep 30, 1997·12 cites·64 claims
- 2144US2004023901A1Nucleoside 5'-monophosphate mimics and their prodrugsFiled 2003·Application pending·0 cites
- 2242US5866698AModulation of gene expression through interference with RNA secondary structureISIS PHARMACEUTICALS INC·Filed 1994·Granted Feb 2, 1999·5 cites·7 claims
- 2333US6368863B1Reagents and methods for modulating gene expression through RNA mimicryISIS PHARMACEUTICALS INC·Filed 1999·Granted Apr 9, 2002·0 cites·7 claims
- 2431US6420109B1Nucleic acid ligand interaction assaysGENELABS TECH INC·Filed 1998·Granted Jul 16, 2002·1 cites·28 claims
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