Assignee
ISIS PHARMACEUTICALS INC
US·895 granted patents·374 pending applications·91,932 citations·filing 1990–2016
Top patents by PatentIndex Score
1,269 records- 0199US9181549B2Conjugated antisense compounds and their useISIS PHARMACEUTICALS INC·Filed 2014·Granted Nov 10, 2015·69 cites·30 claims
- 0299US9127276B2Conjugated antisense compounds and their useISIS PHARMACEUTICALS INC·Filed 2014·Granted Sep 8, 2015·136 cites·6 claims
- 0399US9005906B2Tetrahydropyran nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2014·Granted Apr 14, 2015·163 cites·24 claims
- 0499US8030467B25′-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2010·Granted Oct 4, 2011·327 cites·26 claims
- 0599US8022193B26-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2010·Granted Sep 20, 2011·335 cites·19 claims
- 0699US7750131B25′-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2009·Granted Jul 6, 2010·202 cites·40 claims
- 0799US7745609B2Antisense modulation of CD40 expressionISIS PHARMACEUTICALS INC·Filed 2006·Granted Jun 29, 2010·189 cites·46 claims
- 0899US7741457B26-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2008·Granted Jun 22, 2010·542 cites·24 claims
- 0999US7741305B2Modulation of apolipoprotein (a) expressionISIS PHARMACEUTICALS INC·Filed 2007·Granted Jun 22, 2010·135 cites·27 claims
- 1099US7696345B2Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulationISIS PHARMACEUTICALS INC·Filed 2003·Granted Apr 13, 2010·426 cites·24 claims
- 1199US7695902B2Oligoribonucleotides and ribonucleases for cleaving RNAISIS PHARMACEUTICALS INC·Filed 2002·Granted Apr 13, 2010·201 cites·75 claims
- 1299US7666854B2Bis-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2008·Granted Feb 23, 2010·308 cites·68 claims
- 1399US7629321B2Oligoribonucleotides and ribonucleases for cleaving RNAISIS PHARMACEUTICALS INC·Filed 2002·Granted Dec 8, 2009·146 cites·25 claims
- 1499US7547684B25′-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2007·Granted Jun 16, 2009·413 cites·50 claims
- 1599US7468431B2Modulation of eIF4E-BP2 expressionISIS PHARMACEUTICALS INC·Filed 2005·Granted Dec 23, 2008·117 cites·30 claims
- 1699US7432250B2Oligoribonucleotides and ribonucleases for cleaving RNAISIS PHARMACEUTICALS INC·Filed 2002·Granted Oct 7, 2008·198 cites·12 claims
- 1799US7432249B2Oligoribonucleotides and ribonucleases for cleaving RNAISIS PHARMACEUTICALS INC·Filed 2002·Granted Oct 7, 2008·147 cites·27 claims
- 1899US7399845B26-modified bicyclic nucleic acid analogsISIS PHARMACEUTICALS INC·Filed 2007·Granted Jul 15, 2008·1.1k cites·49 claims
- 1999US7217572B2Modulation of HIF1α and HIF2α expressionISIS PHARMACEUTICALS INC·Filed 2003·Granted May 15, 2007·139 cites·18 claims
- 2099USRE39464EOligonucleolotides having site specific chiral phosphorothioate internucleoside linkagesISIS PHARMACEUTICALS INC·Filed 2004·Granted Jan 9, 2007·235 cites·64 claims
- 2199US7041816B2Process for the synthesis of oligomeric compoundsISIS PHARMACEUTICALS INC·Filed 2004·Granted May 9, 2006·240 cites·17 claims
- 2299US7015315B1Gapped oligonucleotidesISIS PHARMACEUTICALS INC·Filed 1995·Granted Mar 21, 2006·409 cites·30 claims
- 2399US6878805B2Peptide-conjugated oligomeric compoundsISIS PHARMACEUTICALS INC·Filed 2002·Granted Apr 12, 2005·218 cites·38 claims
- 2499US6858715B2Process for the synthesis of oligomeric compoundsISIS PHARMACEUTICALS INC·Filed 2002·Granted Feb 22, 2005·214 cites·35 claims
- 2599US6660720B2Targeted oligonucleotide conjugatesISIS PHARMACEUTICALS INC·Filed 2002·Granted Dec 9, 2003·168 cites·10 claims
- 2699US6600032B12′-O-aminoethyloxyethyl-modified oligonucleotidesISIS PHARMACEUTICALS INC·Filed 1999·Granted Jul 29, 2003·338 cites·31 claims
- 2799US6566135B1Antisense modulation of caspase 6 expressionISIS PHARMACEUTICALS INC·Filed 2000·Granted May 20, 2003·379 cites·13 claims
- 2899US6566131B1Antisense modulation of Smad6 expressionISIS PHARMACEUTICALS INC·Filed 2000·Granted May 20, 2003·366 cites·27 claims
- 2999US6531584B12'modified oligonucleotidesISIS PHARMACEUTICALS INC·Filed 1999·Granted Mar 11, 2003·407 cites·5 claims
- 3099US6525031B2Targeted Oligonucleotide conjugatesISIS PHARMACEUTICALS INC·Filed 2001·Granted Feb 25, 2003·256 cites·22 claims
- 3199US6426220B1Antisense modulation of calreticulin expressionISIS PHARMACEUTICALS INC·Filed 2000·Granted Jul 30, 2002·228 cites·26 claims
- 3299US6365354B1Antisense modulation of lysophospholipase I expressionISIS PHARMACEUTICALS INC·Filed 2000·Granted Apr 2, 2002·366 cites·26 claims
- 3399US6287860B1Antisense inhibition of MEKK2 expressionISIS PHARMACEUTICALS INC·Filed 2000·Granted Sep 11, 2001·334 cites·14 claims
- 3499US6239265B1Oligonucleotides having chiral phosphorus linkagesISIS PHARMACEUTICALS INC·Filed 1998·Granted May 29, 2001·471 cites·10 claims
- 3599US6107094AOligoribonucleotides and ribonucleases for cleaving RNAISIS PHARMACEUTICALS INC·Filed 1997·Granted Aug 22, 2000·938 cites·8 claims
- 3699US5898031AOligoribonucleotides for cleaving RNAISIS PHARMACEUTICALS INC·Filed 1996·Granted Apr 27, 1999·797 cites·66 claims
- 3799US5681941ASubstituted purines and oligonucleotide cross-linkingISIS PHARMACEUTICALS INC·Filed 1994·Granted Oct 28, 1997·1.4k cites·79 claims
- 3899US5677437AHeteroatomic oligonucleoside linkagesISIS PHARMACEUTICALS INC·Filed 1995·Granted Oct 14, 1997·1.3k cites·29 claims
- 3999US5637684APhosphoramidate and phosphorothioamidate oligomeric compoundsISIS PHARMACEUTICALS INC·Filed 1994·Granted Jun 10, 1997·561 cites·21 claims
- 4099US5623070AHeteroatomic oligonucleoside linkagesISIS PHARMACEUTICALS INC·Filed 1995·Granted Apr 22, 1997·1.4k cites·8 claims
- 4199US5587469AOligonucleotides containing N-2 substituted purinesISIS PHARMACEUTICALS INC·Filed 1995·Granted Dec 24, 1996·1.4k cites·29 claims
- 4299US5587361AOligonucleotides having phosphorothioate linkages of high chiral purityISIS PHARMACEUTICALS INC·Filed 1995·Granted Dec 24, 1996·1.4k cites·18 claims
- 4399US5578718AThiol-derivatized nucleosidesISIS PHARMACEUTICALS INC·Filed 1993·Granted Nov 26, 1996·1k cites·25 claims
- 4499US5539083APeptide nucleic acid combinatorial libraries and improved methods of synthesisISIS PHARMACEUTICALS INC·Filed 1994·Granted Jul 23, 1996·782 cites·67 claims
- 4599US5489677AOligonucleoside linkages containing adjacent oxygen and nitrogen atomsISIS PHARMACEUTICALS INC·Filed 1993·Granted Feb 6, 1996·1.8k cites·16 claims
- 4699US5359044ACyclobutyl oligonucleotide surrogatesISIS PHARMACEUTICALS INC·Filed 1991·Granted Oct 25, 1994·1.2k cites·13 claims
- 4799US5223618A4'-desmethyl nucleoside analog compoundsISIS PHARMACEUTICALS INC·Filed 1990·Granted Jun 29, 1993·578 cites·6 claims
- 4898US9181550B2Compositions and methods for modulating apolipoprotein (a) expressionISIS PHARMACEUTICALS INC·Filed 2014·Granted Nov 10, 2015·16 cites·26 claims
- 4998US9163239B2Compositions and methods for modulating apolipoprotein C-III expressionISIS PHARMACEUTICALS INC·Filed 2014·Granted Oct 20, 2015·20 cites·26 claims
- 5098US9145558B2Compositions and methods for modulating HBV expressionISIS PHARMACEUTICALS INC·Filed 2015·Granted Sep 29, 2015·13 cites·24 claims
Showing the top 50 of 1,269 patent records by PatentIndex Score.
Join the waitlist — get patent alerts
Get an alert when ISIS PHARMACEUTICALS INC files or is granted a new patent.
We store only your email — no account needed. See our privacy policy.
Counts cover granted patents and pending applications in the PatentIndex corpus. How scoring works →