Anti-allergic agent

Abstract

The inventors have found that vitamin K3 and vitamin K5 which may be used in pharmaceuticals and foods or ACNQ, DHNA, or the like which can stimulate the growth of bifidobacteria can inhibit degranulation of basophil-like cells, exhibit a potent degranulation-inhibiting effect, and are useful anti-allergic agents or foods. The present invention provides an anti-allergic agent containing, as an active ingredient, one or more species selected from among 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-dihydroxy-2-naphthoic acid, 1,4-naphthoquinone, 4-amino-2-methyl-1-naphthol, 2-methyl-1,4-naphthoquinone, 2-amino-3-chloro-1,4-naphthoquinone, and a salt thereof.

1. A method for treating allergy, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising one or more species selected from the group consisting of 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-dihydroxy-2-naphthoic acid, and a salt thereof, wherein the allergy is allergic rhinitis or allergic dermatitis. 
     
     
       2. The method according to  claim 1 , wherein the composition comprises 2-amino-3-carboxy-1,4-naphthoquinone or a salt thereof. 
     
     
       3. The method according to  claim 1 , wherein the composition comprises 1,4-dihydroxy-2-naphthoic acid or a salt thereof. 
     
     
       4. The method according to  claim 1 , wherein the allergy is allergic rhinitis. 
     
     
       5. The method according to  claim 1 , wherein the allergy is allergic dermatitis.