Methods for the Treatment and Diagnosis of Alzheimer's Disease and Traumatic Brain Injuries

Abstract

The invention relates to the use of HNRNPC-expressing vectors for preventing and/or treating a tauopathy, such as Alzheimer's disease. The invention relates to methods for detecting a risk of developing a tauopathy such Alzheimer's disease in a patient, comprising the step of detecting the level of HNRNPC in a biological sample obtained from said patient.

1 . An expression vector comprising a nucleic acid encoding heterogeneous nuclear ribonuclear protein C (HNRNPC). 
     
     
         2 . The expression vector according to  claim 1 , wherein said expression vector is an adeno-associated vector (AAV). 
     
     
         3 . A method for preventing and/or treating a tauopathy in a patient in need thereof, comprising
 administering a therapeutically effective amount of the expression vector of  claim 1 .   
     
     
         4 . (canceled) 
     
     
         5 . A pharmaceutical composition comprising an expression vector according to  claim 1  and a pharmaceutically acceptable excipient. 
     
     
         6 - 11 . (canceled) 
     
     
         12 . A method for predicting a risk of developing a tauopathy in a patient comprising the step of detecting the Nxnl2 v2/(v1+v2) expression ratio in a biological sample obtained from said patient.