Pharmaceutical formulations

Abstract

A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

What is claimed is: 
     
         1 - 32 . (canceled) 
     
     
         33 . A method for screening for optimal stabilizing concentration of osmolyte comprising the steps of
 a) assessing the stability of a first aqueous solution comprising a first concentration of osmolyte, a therapeutic protein, and a preservative;   b) assessing the stability of a second aqueous solution comprising a different second concentration of osmolyte, a therapeutic protein, and a preservative; and   c) determining that the first concentration of osmolyte is more optimal than the second concentration of osmolyte if the first aqueous solution is more stable.   
     
     
         34 . The method of  claim 33 , wherein the stability is assessed via size exclusion chromatography or circular dichroism.