Closed Loop Control System Based On A Non-Invasive Continuous Sensor

Abstract

Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.

1 - 20 . (canceled) 
     
     
         21 . A method comprising:
 receiving one or more sensor measurements relating to an eye-mountable device exposed to tear-film;   determining a tear-film glucose concentration based on the one or more sensor measurements;   obtaining a target tear-film glucose concentration;   comparing the tear-film glucose concentration to the target tear-film glucose concentration; and   based on the comparing, providing instructions to an insulin delivery device, wherein the instructions control an insulin delivery rate by the insulin delivery device.   
     
     
         22 . The method of  claim 21 , further comprising:
 establishing a rate of change of tear-film glucose concentration based on the one or more sensor measurements, wherein the instructions to the insulin delivery device are further based on the established rate of change of tear-film glucose concentration.   
     
     
         23 . The method of  claim 21 , further comprising:
 establishing a range of tear-film glucose concentrations about the target tear-film glucose concentration based on patient-specific information, wherein providing the instructions comprises:
 providing instructions to maintain a predetermined insulin delivery rate by the insulin delivery device, when the tear-film glucose concentration is within the range; and 
 providing instructions to change the insulin delivery rate by the insulin delivery device, when the tear-film glucose concentration is outside of the range. 
   
     
     
         24 . The method of  claim 21 , wherein the eye-mountable device is in communication with a reader, and wherein receiving the one or more sensor measurements comprises receiving the one or more sensor measurements by way of the reader. 
     
     
         25 . The method of  claim 24 , wherein the reader wirelessly communicates with the eye-mountable device so as to request and receive the one or more sensor measurements. 
     
     
         26 . The method of  claim 24 , wherein the reader is configured to wirelessly power the eye-mountable device. 
     
     
         27 . The method of  claim 24 , wherein the reader is part of a head-mountable device (HMD). 
     
     
         28 . The method of  claim 24 , wherein the instructions are provided to the insulin delivery device by a controller in communication with the reader. 
     
     
         29 . The method of  claim 28 , wherein the controller compares the tear-film glucose concentration to the target tear-film glucose concentration. 
     
     
         30 . The method of  claim 29 , wherein the controller determines the tear-film glucose concentration based on the one or more sensor measurements. 
     
     
         31 . The method of  claim 21 , further comprising obtaining the one or more sensor measurements by a glucose sensor in the eye-mountable device.