Dynamic therapy delivery system

Abstract

Systems for delivery of therapeutic agents and related methods are disclosed. A sensing system is configured to detect a chemical in the vicinity of a patient and transmit a signal to a controller upon detection. A controller is configured to release a therapeutic agent which is transported to the site of interest. The controller communicates with an electronic medical records database, an alarm and a nurse call system.

1 .- 20 . (canceled) 
     
     
         21 . A therapy delivery patch comprising
 a filter sheet for placement adjacent a patient's skin,   an adhesive layer extending outwardly from the filter sheet and configured to attach to the patient's skin,   a cover forming a space above the filter sheet,   a therapeutic agent repository situated within the space,   a flow controller situated within the space and operable to control a flow of therapeutic agent from the therapeutic agent repository through the filter sheet onto the patient's skin.   
     
     
         22 . The therapy delivery patch of  claim 21 , wherein the flow controller is situated between the therapeutic agent repository and the filter sheet. 
     
     
         23 . The therapy delivery patch of  claim 22 , wherein the flow controller comprises a valve. 
     
     
         24 . The therapy delivery patch of  claim 22 , wherein the flow controller comprises a microfluidic pump. 
     
     
         25 . The therapy delivery patch of  claim 21 , further comprising a processor situated in the space, the processor being configured to operate the flow controller to control the flow of therapeutic agent. 
     
     
         26 . The therapy delivery patch of  claim 25 , further comprising at least one sensor that detects a chemical secretion of the patient. 
     
     
         27 . The therapy delivery patch of  claim 26 , wherein the processor operates the flow controller to control the flow of therapeutic agent based on a signal received from the at least one sensor. 
     
     
         28 . The therapy delivery patch of  claim 26 , wherein the at least one sensor extends through the filter sheet. 
     
     
         29 . The therapy delivery patch of  claim 26 , wherein the at least one sensor is situated between the flow controller and the patient's skin. 
     
     
         30 . The therapy delivery patch of  claim 26 , wherein the at least one sensor comprises one or more of the following: a metal oxide type semi-conductor (MOS) sensor, a capacitive sensor, an inductive sensor or a surface acoustic wave sensor. 
     
     
         31 . The therapy delivery patch of  claim 26 , wherein the at least one sensor comprises a protein based biosensor. 
     
     
         32 . The therapy delivery patch of  claim 31 , wherein the protein based biosensor comprises one or more of the following: an odarant binding protein (OBP), a sensory appendage protein (SAP), an odorant receptor, a gustatory receptor, a serpentine receptor, or an odarant degrading enzyme (ODE). 
     
     
         33 . The therapy deliver patch of  claim 31 , wherein the at least one sensor further comprises an electrochemical transducer to generate an electrical signal in response to detection of a chemical by the protein based biosensor. 
     
     
         34 . The therapy delivery patch of  claim 26 , wherein the at least one sensor detects an indication of Ischemia by detecting any one or more of the following: CO 2 , Urea, Urate, Chloride, Lactic Acid, CO 2 /O 2  or O 2 . 
     
     
         35 . The therapy delivery patch of  claim 26 , wherein the at least one sensor detects a 1L-1α and Creatine Phosphokinase (CPK) which is indicative of wound development. 
     
     
         36 . The therapy delivery patch of  claim 21 , wherein the therapeutic agent comprises a vasodilator. 
     
     
         37 . The therapy delivery patch of  claim 36 , wherein the vasodilator comprises one or more of the following: histamine, niacin, potassium or nitric acid. 
     
     
         38 . The therapy delivery patch of  claim 21 , wherein the cover forms a dome over the filter sheet. 
     
     
         39 . The therapy delivery patch of  claim 38 , wherein a bottom of the dome is located near a junction between the adhesive layer and the filter sheet. 
     
     
         40 . The therapy delivery patch of  claim 38 , wherein the therapeutic agent repository is situated between the flow controller and a top of the dome.