Dermatological compositions comprising retinoids, dispersed benzoyl peroxide and carrageenans

Abstract

Dermatological compositions containing, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and at least one gelling agent of the family of the carrageenans, are useful for treating dermatological conditions and afflictions linked to disorders of cell differentiation and/or proliferation and/or keratinization, notably for treating acne vulgaris.

What is claimed is: 
     
         1 . A topically applicable, chemically, physically and rheologically stable dermatological composition suited for treating dermatological conditions and afflictions linked to disorders of cell differentiation and/or proliferation and/or keratinization, comprising thus effective amounts of at least one retinoid, dispersed benzoyl peroxide and at least one carrageenan gelling agent, formulated into a topically applicable, physiologically acceptable medium therefore. 
     
     
         2 . The dermatological composition as defined by  claim 1 , said at least one retinoid comprising a naphthoic acid compound. 
     
     
         3 . The dermatological composition as defined by  claim 1 , comprising from 0.1 to 20% by weight with respect to the total weight of the composition, of carrageenan. 
     
     
         4 . The dermatological composition as defined by  claim 1 , further comprising at least one additional gelling agent. 
     
     
         5 . The dermatological composition as defined by  claim 4 , said at least one additional gelling agent comprising a semisynthetic cellulose, polysaccharide gum, silicate, acrylic polymer coupled to a hydrophobic chain, modified starch and/or polyacrylamide. 
     
     
         6 . The dermatological composition as defined by  claim 5 , wherein the amount of additional gelling agent ranges from 0.01% to 20% by weight, with respect to the total weight of the composition. 
     
     
         7 . The dermatological composition as defined by  claim 1 , comprising from 0.0001% to 20% of said at least one retinoid by weight, with respect to the total weight of the composition. 
     
     
         8 . The dermatological composition as defined by  claim 1 , said at least one retinoid comprising adapalene. 
     
     
         9 . The dermatological composition as defined by  claim 1 , comprising from 0.0001% to 20% of benzoyl peroxide by weight, with respect to the total weight of the composition. 
     
     
         10 . The dermatological composition as defined by  claim 1 , wherein the benzoyl peroxide is encapsulated. 
     
     
         11 . The dermatological composition as defined by  claim 1 , further comprising at least one propenetrating agent. 
     
     
         12 . The dermatological composition as defined by  claim 11 , comprising from 0.01% to 20% of propenetrating agent by weight, with respect to the total weight of the composition. 
     
     
         13 . The dermatological composition as defined by  claim 9 , said at least one propenetrating agent comprising propylene glycol. 
     
     
         14 . The dermatological composition as defined by  claim 1 , further comprising at least one wetting liquid surfactant. 
     
     
         15 . The dermatological composition as defined by  claim 14 , comprising from 0.01% to 10% of wetting liquid surfactant by weight, with respect to the total weight of the composition. 
     
     
         16 . The dermatological composition as defined by  claim 15 , said at least one wetting liquid surfactant comprising a poloxamer. 
     
     
         17 . The dermatological composition as defined by  claim 1 , formulated as a gel. 
     
     
         18 . The dermatological composition as defined by  claim 1 , comprising, formulated into a physiologically acceptable medium (expressed as percentage by weight):
 from 20 to 90% of water;   from 0.01 to 10% of wetting agents;   from 0.0001 to 20% of benzoyl peroxide;   from 0.0001 to 20% of at least one retinoid;   from 0.1 to 20% of at least one carrageenan;   from 0 to 10% of cations;   from 0.01 to 15% of one or more humectants and/or emollients;   from 0.01 to 10% of additional gelling agent and/or suspending agent and/or pH-independent gelling agent; and   from 0 to 20% of additives.   
     
     
         19 . The dermatological composition as defined by  claim 1 , formulated as an emulsion. 
     
     
         20 . The dermatological composition as defined by  claim 1 , comprising, formulated into a physiologically acceptable medium (expressed as percentage by weight):
 from 20 to 90% of water;   from 0.01 to 10% of wetting agents;   from 0.0001 to 20% of benzoyl peroxide;   from 0.0001 to 20% of at least one retinoid;   from 0.1 to 20% of at least one carrageenan;   from 0 to 10% of cations;   from 0.01 to 15% of one or more humectants and/or emollients;   from 0.01 to 10% of additional gelling agent and/or suspending agent and/or pH-independent gelling agent;   from 0 to 15% of emulsifiers; and   from 0 to 20% of additives.   
     
     
         21 . The dermatological composition as defined by  claim 1 , formulated as a medicament. 
     
     
         22 . A regime or regimen for preventing or treating dermatological conditions or afflictions linked to disorders of cell differentiation and/or proliferation and/or of keratinization, comprising administering to an individual in need of such treatment, a thus effective amount of a dermatological composition as defined by  claim 1 . 
     
     
         23 . A regime or regimen for treating acne vulgaris, comprising administering to an individual in need of such treatment, a thus effective amount of a dermatological composition as defined by  claim 1 . 
     
     
         24 . A regime or regimen for the treatment of skin with a tendency towards acne, for causing hair growth or preventing hair loss, for combating the greasy appearance of the skin or hair, for protecting against the harmful effects of the sun or for treating physiologically greasy skin, or for preventing and/or for combating photoinduced or chronologic aging, comprising administering to an individual in need of such treatment, a thus effective amount of a dermatological composition as defined by  claim 1 .