US2012040887A1PendingUtilityA1

Composition for the treatment of osteomyelitis, method for preparing the same, and method for the treatment of osteomyelitis

33
Assignee: CHEN CHIN-FUPriority: Aug 16, 2010Filed: Oct 7, 2010Published: Feb 16, 2012
Est. expiryAug 16, 2030(~4.1 yrs left)· nominal 20-yr term from priority
Inventors:Chin-Fu ChenHsin-Hsin ShenYu-Min LeeI-Ming ChuKuo-Ti Peng
A61P 31/04A61K 47/34A61K 9/107A61K 9/0019A61K 38/14A61K 31/785A61P 19/00
33
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

The disclosure provides a composition for the treatment of osteomyelitis and a method for preparing the same. The composition includes: 100 parts by weight of water; 0.06-0.1 parts by weight of an antibiotic; and 5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following: wherein, R 1 is hydrogen, or —C(═O)—R 2 ; R 2 is C 7-30 alkyl substituted or unsubstituted with functional groups; R 3 is hydrogen, or C 1-6 alkyl; and x, y or z individually are integers greater than 0.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A composition for the treatment of osteomyelitis, comprising:
 100 parts by weight of water;   0.06-0.1 parts by weight of an antibiotic; and   5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following:   
       
         
           
           
               
               
           
         
         wherein, R 1  is hydrogen, or —C(═O)—R 2 ; R 2  is C 7-30  alkyl substituted or unsubstituted with functional groups; R 3  is hydrogen, or C 1-6  alkyl; and x, y or z individually are integers greater than 0. 
       
     
     
         2 . The composition as claimed in  claim 1 , wherein the antibiotic comprises teicoplanin, vancomycin, telavancin, neomycin, or tobromycin. 
     
     
         3 . The composition as claimed in  claim 1 , wherein the ration between x+y and z is from 1.8 to 2.8. 
     
     
         4 . The composition as claimed in  claim 1 , wherein the composition exhibited a solution state below 10° C. and above 50° C., and the composition exhibited a sol-gel state between 10-50° C. 
     
     
         5 . A method for preparing a composition for the treatment of osteomyelitis, comprising:
 mixing the following components:   100 parts by weight of water;   0.06-0.1 parts by weight of an antibiotic; and   5-40 parts by weight of a biodegradable thermosensitive polymer, wherein the biodegradable thermosensitive polymer has a structure as following:   
       
         
           
           
               
               
           
         
         wherein, R 1  is hydrogen, or —C(═O)—R 2 ; R 2  is C 7-30  alkyl substituted or unsubstituted with functional groups; R 3  is hydrogen, or C 1-6  alkyl; and x, y or z individually are integers greater than 0. 
       
     
     
         6 . A method for the treatment of osteomyelitis, comprising:
 intramuscularly administering the composition of  claim 1  to a subject suffering from osteomyelitis under conditions such that said osteomyelitis is reduced.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.