US2011027338A1PendingUtilityA1

Biologic replacement for fibrin clot

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Assignee: CHILDRENS MEDICAL CENTERPriority: Jun 22, 1999Filed: Oct 7, 2010Published: Feb 3, 2011
Est. expiryJun 22, 2019(expired)· nominal 20-yr term from priority
Inventors:Martha M. MurrayMichael F. MurrayJennifer Marler
A61P 43/00A61P 41/00A61L 24/102A61L 27/3662A61L 2430/10A61L 24/043A61L 27/3616A61L 2430/02A61P 17/00Y10S623/917A61L 27/3645A61L 27/3804A61L 27/3654A61L 2430/06A61L 27/26A61P 19/00A61P 19/04A61L 27/24A61K 38/39A61P 17/02A61L 27/3843A61L 27/365
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Claims

Abstract

The invention provides composition and methods for repairing a ruptured anterior cruciate ligament.

Claims

exact text as granted — not AI-modified
1 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises plasma. 
     
     
         2 . The scaffold according to  claim 1 , wherein said tissue defect is extra-articular. 
     
     
         3 . The scaffold according to  claim 1 , wherein said tissue defect is intra-articular. 
     
     
         4 . The scaffold according to  claim 1 , wherein said tissue defect comprises a ligament. 
     
     
         5 . The scaffold according to  claim 1 , wherein said tissue defect comprises a tendon. 
     
     
         6 . The scaffold according to  claim 1 , wherein said tissue defect comprises bone. 
     
     
         7 . The scaffold according to  claim 1 , wherein said tissue defect comprises cartilage. 
     
     
         8 . The scaffold according to  claim 1 , wherein said tissue defect is bridged with natural or synthetic graft tissue or patch 
     
     
         9 . The scaffold according to  claim 1 , wherein said tissue defect is a partial or complete tear of a ligament. 
     
     
         10 . The scaffold according to  claim 1 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL). 
     
     
         11 . The scaffold according to  claim 1 , wherein said tissue defect is a partial or complete tear of the rotator cuff. 
     
     
         12 . The scaffold according to  claim 1 , wherein said tissue defect is a partial or complete tear of the labrum. 
     
     
         13 . The scaffold according to  claim 1 , wherein said tissue defect is a partial or complete tear of the meniscus. 
     
     
         14 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a platelet. 
     
     
         15 . The scaffold according to  claim 14 , wherein said tissue defect is extra-articular. 
     
     
         16 . The scaffold according to  claim 14 , wherein said tissue defect is intra-articular. 
     
     
         17 . The scaffold according to  claim 14 , wherein said tissue defect comprises a ligament. 
     
     
         18 . The scaffold according to  claim 14 , wherein said tissue defect comprises a tendon. 
     
     
         19 . The scaffold according to  claim 14 , wherein said tissue defect comprises bone. 
     
     
         20 . The scaffold according to  claim 14 , wherein said tissue defect comprises cartilage. 
     
     
         21 . The scaffold according to  claim 14 , wherein said tissue defect is bridged with natural or synthetic graft tissue or patch 
     
     
         22 . The scaffold according to  claim 14 , wherein said tissue defect is a partial or complete tear of a ligament. 
     
     
         23 . The scaffold according to  claim 14 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL). 
     
     
         24 . The scaffold according to  claim 14 , wherein said tissue defect is a partial or complete tear of the rotator cuff. 
     
     
         25 . The scaffold according to  claim 14 , wherein said tissue defect is a partial or complete tear of the labrum. 
     
     
         26 . The scaffold according to  claim 14 , wherein said tissue defect is a partial or complete tear of the meniscus. 
     
     
         27 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a neutralizing agent. 
     
     
         28 . The scaffold according to  claim 27 , wherein said tissue defect is extra-articular. 
     
     
         29 . The scaffold according to  claim 27 , wherein said tissue defect is intra-articular. 
     
     
         30 . The scaffold according to  claim 27 , wherein said tissue defect comprises a ligament. 
     
     
         31 . The scaffold according to  claim 27 , wherein said tissue defect comprises a tendon. 
     
     
         32 . The scaffold according to  claim 27 , wherein said tissue defect comprises bone. 
     
     
         33 . The scaffold according to  claim 27 , wherein said tissue defect comprises cartilage. 
     
     
         34 . The scaffold according to  claim 27 , wherein said tissue defect is bridged with natural or synthetic graft tissue or patch 
     
     
         35 . The scaffold according to  claim 27 , wherein said tissue defect is a partial or complete tear of a ligament. 
     
     
         36 . The scaffold according to  claim 27 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL). 
     
     
         37 . The scaffold according to  claim 27 , wherein said tissue defect is a partial or complete tear of the rotator cuff. 
     
     
         38 . The scaffold according to  claim 27 , wherein said tissue defect is a partial or complete tear of the labrum. 
     
     
         39 . The scaffold according to  claim 27 , wherein said tissue defect is a partial or complete tear of the meniscus. 
     
     
         40 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of neutralized soluble type I collagen gel. 
     
     
         41 . The scaffold according to  claim 40 , wherein said tissue defect is extra-articular. 
     
     
         42 . The scaffold according to  claim 40 , wherein said tissue defect is intra-articular. 
     
     
         43 . The scaffold according to  claim 40 , wherein said tissue defect comprises a ligament. 
     
     
         44 . The scaffold according to  claim 40 , wherein said tissue defect comprises a tendon. 
     
     
         45 . The scaffold according to  claim 40 , wherein said tissue defect comprises bone. 
     
     
         46 . The scaffold according to  claim 40 , wherein said tissue defect comprises cartilage. 
     
     
         47 . The scaffold according to  claim 40 , wherein said tissue defect is bridged with natural or synthetic graft tissue or patch 
     
     
         48 . The scaffold according to  claim 40 , wherein said tissue defect is a partial or complete tear of a ligament. 
     
     
         49 . The scaffold according to  claim 40 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL). 
     
     
         50 . The scaffold according to  claim 40 , wherein said tissue defect is a partial or complete tear of the rotator cuff. 
     
     
         51 . The scaffold according to  claim 40 , wherein said tissue defect is a partial or complete tear of the labrum. 
     
     
         52 . The scaffold according to  claim 40 , wherein said tissue defect is a partial or complete tear of the meniscus.

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