US2005250102A1PendingUtilityA1

Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1

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Assignee: UNIV JOHNS HOPKINSPriority: Apr 28, 1995Filed: Jul 24, 2003Published: Nov 10, 2005
Est. expiryApr 28, 2015(expired)· nominal 20-yr term from priority
Inventors:Jin-Tang DongJ. BarrettPatricia W. LambJohn T. Isaacs
C07K 16/3069A61P 35/04A61P 35/00C07K 14/70596C12Q 2600/112C12Q 1/6886G01N 33/575
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Abstract

The isolation and characterization of a metastasis tumor suppressor gene KAI 1 is disclosed and diagnostic methods and gene therapy approaches utilizing reagents derived from the nucleotide and deduced amino acid sequences of the KAI 1 gene are provided.

Claims

exact text as granted — not AI-modified
1 . A method for detecting the presence of malignant cancer in a subject comprising: 
 comparing KAI1 gene sequence, KAI1 mRNA or KAI1 protein of said subject to wild-type KAI1 gene sequence, mRNA or protein, an observed alteration of KAI1 gene sequence, KAI1 mRNA, or KAI1 protein of said subject as compared to wild-type indicating the presence of malignant cancer in said subject.    
     
     
         2 - 21 . (canceled)

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